Oscillatory phase coupling coordinates anatomically dispersed functional cell assemblies
Oscillatory phase coupling coordinates anatomically dispersed functional cell assemblies
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DOI：
10.1073/pnas.1008306107
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发表时间：
2010-10-05
影响因子：
11.1
通讯作者：
Carmena, Jose M.
中科院分区：
文献类型：
--
作者：
Canolty, Ryan T.;Ganguly, Karunesh;Carmena, Jose M.
Hebb提出，神经细胞组装对有效的感知、认知和行动至关重要。然而，关于大脑协调多个相互作用的组件的机制的证据仍然缺乏。神经元振荡被认为是细胞组装协调的一种可能机制。以往的研究表明，放电的时序依赖于细胞体近端的局部场电位(LFP)相，但很少有研究研究远离神经元的其他脑区的尖峰电位对远端LFP相的依赖性，或者远端区域之间的LFP-LFP位相耦合对尖峰电位的影响。我们通过在几个脑区使用多个微电极阵列记录LFP和单个单位的活动来研究这些相互作用，然后使用唯一的概率多变量相位分布来模拟尖峰定时对近端LFP相、远端LFP相和电极之间的LFP-LFP相耦合的完整模式的依赖。在这里，我们表明，单个神经元和神经元群的放电活动取决于多个脑区之间振荡相耦合的动态模式，以及近端LFP相的影响。喜欢相似相耦合模式的神经元在尖峰频率上表现出相似的变化，而不同偏好的神经元表现出不同的反应，这为将不同的神经元结合在一起形成协调的细胞集合提供了基本的机制。令人惊讶的是，基于相位耦合的速率相关性与神经元间距离无关。相耦合偏好与行为和神经功能相关，并在多天内保持稳定。这些发现表明，神经元振荡能够选择性和动态地控制分布的功能细胞组件。
Hebb proposed that neuronal cell assemblies are critical for effective perception, cognition, and action. However, evidence for brain mechanisms that coordinate multiple coactive assemblies remains lacking. Neuronal oscillations have been suggested as one possible mechanism for cell assembly coordination. Prior studies have shown that spike timing depends upon local field potential (LFP) phase proximal to the cell body, but few studies have examined the dependence of spiking on distal LFP phases in other brain areas far from the neuron or the influence of LFP-LFP phase coupling between distal areas on spiking. We investigated these interactions by recording LFPs and single-unit activity using multiple microelectrode arrays in several brain areas and then used a unique probabilistic multivariate phase distribution to model the dependence of spike timing on the full pattern of proximal LFP phases, distal LFP phases, and LFP-LFP phase coupling between electrodes. Here we show that spiking activity in single neurons and neuronal ensembles depends on dynamic patterns of oscillatory phase coupling between multiple brain areas, in addition to the effects of proximal LFP phase. Neurons that prefer similar patterns of phase coupling exhibit similar changes in spike rates, whereas neurons with different preferences show divergent responses, providing a basic mechanism to bind different neurons together into coordinated cell assemblies. Surprisingly, phase-coupling-based rate correlations are independent of interneuron distance. Phase-coupling preferences correlate with behavior and neural function and remain stable over multiple days. These findings suggest that neuronal oscillations enable selective and dynamic control of distributed functional cell assemblies.