Enhancement of immune responses to an HBV DNA vaccine by electroporation
Enhancement of immune responses to an HBV DNA vaccine by electroporation
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DOI：
10.1016/j.vaccine.2005.08.014
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发表时间：
2006-05-22
期刊：
影响因子：
5.5
通讯作者：
Bernard, R
中科院分区：
文献类型：
--
作者：
Luxembourg, A;Hannaman, D;Bernard, R
这些研究证明，基于电穿孔 (EP) 的 DNA 疫苗接种能够在正常小鼠中诱导对乙型肝炎病毒 (HBV) DNA 疫苗接种的多特异性 CTL 反应，并在较大动物物种中对多价 HBV DNA 免疫产生显着的免疫反应。这些结果表明，电穿孔介导的 HBV DNA 疫苗接种作为慢性 HBV 感染的治疗方法值得追求。 (c) 2005 Elsevier Ltd. 保留所有权利。
These studies document the ability of electroporation (EP)-based DNA vaccination to induce multi-specific CTL responses to hepatitis B virus (HBV) DNA vaccination in normal mice and marked immune responses to multivalent HBV DNA immunization in larger animal species. These results suggest that electroporation-mediated HBV DNA vaccination is worth pursuing as a treatment for chronic HBV infection. (c) 2005 Elsevier Ltd. All rights reserved.