ACUTE EFFECTS OF ETHANOL AND ACETALDEHYDE ON BLOOD-PRESSURE AND HEART-RATE IN DISULFIRAM-TREATED AND CONTROL RATS
ACUTE EFFECTS OF ETHANOL AND ACETALDEHYDE ON BLOOD-PRESSURE AND HEART-RATE IN DISULFIRAM-TREATED AND CONTROL RATS
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DOI：
10.1016/0091-3057(82)90102-2
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发表时间：
1982-01-01
影响因子：
3.6
通讯作者：
TOTTMAR, O
中科院分区：
文献类型：
--
作者：
HELLSTROM, E;TOTTMAR, O
在对照大鼠和双硫仑预处理的大鼠中研究了乙醇和乙醛对心血管的影响。对照组大鼠给予乙醇可显著降低平均血压和增加心率。对双硫仑治疗的大鼠注射乙醇降低了平均血压，增加了脉压、心率和呼吸频率。血液乙醛水平比对照组高10-15倍。在乙醇给药前或给药后给予4-甲基吡唑的大鼠中，双硫仑给药大鼠中乙醇引起的效应被预防或消除。在静脉内给予乙醛的对照大鼠中，心率随着乙醛浓度的增加而增加。在高乙醛水平（150-250 μ M）下仅观察到平均血压轻微降低;脉压以及呼吸频率显著增加。在乙醛水平< 50 μ M时，没有观察到对血压的影响。在双硫仑治疗的大鼠中输注乙醛的效果与在具有相当乙醛水平的对照组中观察到的效果相似。大鼠双硫仑-乙醇反应是乙醇和乙酰胆碱对心血管系统的联合作用所致。
The cardiovascular effects of ethanol and acetaldehyde were studied in control rats and rats pretreated with disulfiram. Ethanol administration to control rats decreased mean blood pressure and increased heart rate significantly. Injection of ethanol to disulfiram-treated rats decreased mean blood pressure and increased pulse pressure, heart rate and respiratory rate. The blood acetaldehyde levels were 10-15 times higher than those found in controls. The effects evoked by ethanol in disulfiram-treated rats were prevented or abolished in rats given 4-methylpyrazole before or after ethanol. Heart rate increased with increasing concentrations of acetaldehyde in control rats given acetaldehyde i.v. Only a slight decrease in mean blood pressure was seen at high acetaldehyde levels (150-250 .mu.M); pulse pressure increased markedly as well as respiratory rate. At acetaldehyde levels < 50 .mu.M, no effects on blood pressure were seen. The effects of acetaldehyde infusion in disulfiram-treated rats were similar to those observed in controls having comparable acetaldehyde levels. The disulfiram-ethanol reaction in rats is apparently caused by the combined action of ethanol and acetaldehye on the cardiovascular system.