DISTRIBUTION OF ENTERIC NEURONS SHOWING IMMUNOREACTIVITY FOR SUBSTANCE-P IN THE GUINEA-PIG ILEUM
DISTRIBUTION OF ENTERIC NEURONS SHOWING IMMUNOREACTIVITY FOR SUBSTANCE-P IN THE GUINEA-PIG ILEUM
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DOI：
10.1016/0306-4522(80)90108-6
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发表时间：
1980-01-01
期刊：
影响因子：
3.3
通讯作者：
FRANCO, R
中科院分区：
文献类型：
--
作者：
COSTA, M;CUELLO, AC;FRANCO, R
P物质样免疫反应性定位于豚鼠回肠的隔离层的整个安装准备。含有P物质的轴突在神经细胞周围形成密集的网络，并在肌间神经丛的初级，次级和三级神经束中运行。三点六%的肌间神经丛的神经细胞体和11.3%的粘膜下神经丛中的细胞体显示P物质的免疫反应性。轴突在细神经束平行于纵向肌肉，肌肉和肌间神经丛之间。含有P物质的轴突也在小神经干中平行于环形肌贯穿其厚度和在该肌被基部的深肌丛中。在粘膜下层，这些轴突在神经丛的神经节细胞之间分支，并在结间股中运行。此外，它们在粘膜下动脉周围形成血管周围网络，并对这些动脉之后的血管旁神经做出贡献。含有P物质的轴突在粘膜中形成一个精致的丛。外源性失神经支配后，与粘膜下动脉相关的含P物质的神经和粘膜下神经丛中的一些神经消失。其他区域的神经与正常情况没有明显差异。与生长抑素、脑啡肽和血管活性肠肽的分布比较表明，含P物质的神经元在肠神经系统中构成一个独立的群体。
Substance P-like immunoreactivity was localized in whole mount preparations of the isolated layers of the guinea-pig ileum. Axons containing substance P formed dense networks around the nerve cells and ran in the primary, secondary and tertiary nerve bundles of the myenteric plexus. Three point six % of the nerve cell bodies of the myenteric plexus and 11.3% of the cell bodies in the submucous plexus showed immunoreactivity for substance P. Axons ran in fine nerve bundles parallel to the longitudinal muscle, between this muscle and the myenteric plexus. Axons containing substance P also ran in small nerve trunks parallel to the circular muscle throughout its thickness and in the deep muscular plexus at the base of this muscle coat. In the submucosa, these axons ramified amongst ganglion cells of the plexus and ran in the internodal strands. In addition they formed a perivascular network around submucous arteries and contributed to the paravascular nerves following these arteries. Axons containing substance P formed a delicate plexus in the mucosa. After extrinsic denervation the nerves containing substance P that were associated with submucous arteries, and some in the submucous plexus, disappeared. The nerves in the other areas were not detectably different from normal. Comparison with the distribution of somatostatin, enkephalin and vasoactive intestinal polypeptide indicated the neurons containing substance P constitute a separate population within the enteric nervous system.