Mitochondrial defects in cancer.
Mitochondrial defects in cancer.
复制标题
DOI：
10.1186/1476-4598-1-9
复制
发表时间：
2002-12-09
期刊：
影响因子：
37.3
通讯作者：
Huang P
中科院分区：
文献类型：
--
作者：
Carew JS;Huang P
线粒体在细胞能量代谢、自由基生成和细胞凋亡中起重要作用。线粒体功能的缺陷长期以来一直被怀疑有助于癌症的发展和进展。在这篇综述文章中，我们的目的是提供一个简短的总结，我们目前的理解线粒体遗传学和生物学，审查报告的mtDNA改变在各种类型的癌症，并提供一些观点，以mtDNA突变的出现，其功能后果在癌症的发展，和治疗意义。
Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Defects in mitochondrial function have long been suspected to contribute to the development and progression of cancer. In this review article, we aim to provide a brief summary of our current understanding of mitochondrial genetics and biology, review the mtDNA alterations reported in various types of cancer, and offer some perspective as to the emergence of mtDNA mutations, their functional consequences in cancer development, and therapeutic implications.