Human thymic epithelial cells: adhesion molecules and cytokine production.
Human thymic epithelial cells: adhesion molecules and cytokine production.
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人胸腺上皮细胞：粘附分子和细胞因子的产生。
DOI：
10.1007/bf02592284
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Singer,KH
中科院分区：
文献类型：
--
作者：
Le,PT;Singer,KH
培养人胸腺上皮细胞的能力极大地促进了体外胸腺上皮细胞和T淋巴细胞之间的直接细胞-细胞相互作用以及细胞因子产生和细胞因子产生的调节的研究。在体外，人胸腺上皮细胞通过两种粘附途径与T淋巴细胞结合：CD 2-淋巴细胞功能相关抗原-3和淋巴细胞功能相关抗原-1-细胞间粘附分子-1。培养的人胸腺上皮细胞产生白细胞介素-1 α、-1 β、-3、-6和-8、粒细胞集落刺激因子、巨噬细胞集落刺激因子、粒细胞-巨噬细胞集落刺激因子、白血病抑制因子和转化生长因子-α。胸腺上皮细胞驱动的细胞因子的产生由粘附分子（淋巴细胞功能相关抗原-3）和可溶性因子通过自分泌（白细胞介素-1 α、转化生长因子-α）和旁分泌（白细胞介素-4、干扰素-γ）途径调节。转化生长因子-α和表皮生长因子通过增加细胞因子mRNA的稳定性在转录后水平调节各种细胞因子mRNA。
The ability to culture human thymic epithelial cells has greatly facilitated studies of direct cell-cell interaction between thymic epithelial cells and T lymphocytes in vitro, as well as cytokine production and regulation of cytokine production. In vitro, human thymic epithelial cells bind to T lymphocytes via two adhesion pathways: CD2-lymphocyte function-associated antigen-3 and lymphocyte function-associated antigen-1-intercellular adhesion molecule-1. Cultured human thymic epithelial cells produce interleukins-1α, −1β, −3, −6 and −8, granulocyte colony-stimulating factor, macrophage colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, leukemia inhibitory factor and transforming growth factor-α. Production of thymic epithelial cell-drived cytokines is regulated by both adhesion molecules (lymphocyte function-associated antigen-3) and soluble factors via both autocrine (interleukin-1α, transforming growth factor-α) and paracrine (interleukin-4, interferon-γ) pathways. Transforming growth factor-α and epidermal growth factor regulate various cytokine mRNA at a post-transcriptional level by increasing cytokine mRNA stability.