Vestibular compensation: a review of the oculomotor, neural, and clinical consequences of unilateral vestibular loss.
Vestibular compensation: a review of the oculomotor, neural, and clinical consequences of unilateral vestibular loss.
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DOI：
10.1016/0957-4271(94)00026-x
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发表时间：
1995-03-01
期刊：
影响因子：
--
通讯作者：
Halmagyi, G M
中科院分区：
文献类型：
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作者：
Curthoys, I S;Halmagyi, G M
前庭感觉输入只是涉及凝视和姿势等功能控制的一种感觉输入。回顾了部分或完全单侧前庭输入丧失后凝视和姿势控制的恢复。单侧前庭丧失后相对快速且明显完全的行为恢复一度被认为证明前庭补偿被用作中枢神经系统可塑性的教科书示例。这篇评论强调了这种印象是多么错误：详细的检查表明，前庭代偿不是一个快速完全恢复的单一过程，而是由许多恢复到不同水平和不同速度的子过程组成。在某些子流程中，恢复非常有限；在其他子过程中，可能会用其他感觉输入替代受影响的前庭输入。在某些情况下，似乎还可以学习新的行为策略，使目光和姿势控制能够像正常情况一样进行。回顾了有关前庭代偿生理和药理学机制的最新证据。
Vestibular sensory input is just one sensory input involved in the control of functions such as gaze and posture. The recovery of gaze and posture control after partial or complete unilateral loss of vestibular input is reviewed. The relatively rapid and apparently complete behavioral recovery after unilateral vestibular loss was once regarded as justifying vestibular compensation being used as a text-book example of plasticity in the CNS. This review emphasizes how false that impression is: Detailed examination shows that vestibular compensation is not a single process that recovers completely at a rapid rate but is made up of a number of subprocesses that recover to different levels and at different rates. In some subprocesses there is very modest recovery; in other subprocesses there is probably substitution of other sensory input for the affected vestibular input. It also seems that in some instances new behavioral strategies appear to be learned to allow gaze and posture control to operate as if normal. Recent evidence concerning the physiological and pharmacological mechanisms underlying vestibular compensation is reviewed.