Immunoglobulin allotypes among the Bicolanos of Sorsogon province, Luzon, Philippines: implications of phenotypes for filariasis.
Immunoglobulin allotypes among the Bicolanos of Sorsogon province, Luzon, Philippines: implications of phenotypes for filariasis.
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菲律宾吕宋岛索索贡省比科拉诺人的免疫球蛋白同种异型：表型对丝虫病的影响。
DOI：
10.1159/000019097
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Pandey,JP
中科院分区：
文献类型：
--
作者：
Kron,MA;Ramirez,B;BelizarioJr,V;Pandey,JP
免疫球蛋白（Ig）同种异体是多态遗传系统，显示出不同的种族阵列，因此使它们成为研究遗传混合和生物关系的有力工具。在菲律宾吕宋岛南部的索索贡省，对居住在两个相邻村庄的252人完成了同种型分析。这些人表现出14种GM和3种KM表型。纯合子KM3、KM1和杂合子KM1、3的频率相同；然而，在一个村庄出现的一半转基因表型在另一个村庄明显不那么常见。KM和GM单倍型的频率与菲律宾土著群体中报道的不同，但与Samar岛的人群相似，Samar岛是唯一一个存在Ig同种型数据的菲律宾群体。淋巴丝虫病等寄生虫病流行率的差异可能部分反映了遗传易感性的差异，这是由村庄之间的异型异质性造成的。
Immunoglobulin (Ig) allotypes are polymorphic genetic systems that show distinct racial arrays, thus making them powerful tools for studies of genetic admixture and biological relationships. In the province of Sorsogon, southern Luzon, Philippines, allotyping was completed on 252 persons residing in two neighboring villages. The people demonstrated 14 GM and 3 KM phenotypes. The frequency of homozygous KM3, KM1 and heterozygous KM1,3 was identical in these villages; however, half of the GM phenotypes present in one village were significantly less frequent in the other village. The frequency of KM and GM haplotypes was different from those reported in Filipino aboriginal groups, but similar to a population on Samar Island, the only other Filipino group for which Ig allotype data exist. Variability in the prevalence of parasitic disease such as lymphatic filariasis may in part reflect differences in genetic susceptibility, resulting from allotypic heterogeneity between villages.