Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique
Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique
复制标题
DOI：
10.1155/2011/132435
复制
发表时间：
2011-01-01
影响因子：
2.7
通讯作者：
Trotta, Michele
中科院分区：
文献类型：
--
作者：
Gallarate, Marina;Battaglia, Luigi;Trotta, Michele
根据一种称为凝聚的新技术制备了硬脂酸固体脂质纳米粒。本实验工作的主要目标是将肽类药物包埋到SLN中，这是一项艰巨的任务，因为它们的化学特性（分子量、亲水性和稳定性）妨碍了含肽制剂。以胰岛素和亮丙瑞林为模型肽类药物，通过与阴离子表面活性剂的疏水离子配对，将其包裹在纳米粒中。包封后肽的完整性得以保持，并且纳米颗粒可以作为肽的体外缓释系统。
Stearic acid solid lipid nanoparticles were prepared according to a new technique, called coacervation. The main goal of this experimental work was the entrapment of peptide drugs into SLN, which is a difficult task, since their chemical characteristics (molecular weight, hydrophilicity, and stability) hamper peptide-containing formulations. Insulin and leuprolide, chosen asmodel peptide drugs, were encapsulated within nanoparticles after hydrophobic ion pairing with anionic surfactants. Peptide integrity was maintained after encapsulation, and nanoparticles can act in vitro as a sustained release system for peptide.