In vivo continuous-wave optical breast imaging enhanced with Indocyanine Green
In vivo continuous-wave optical breast imaging enhanced with Indocyanine Green
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DOI：
10.1118/1.1573791
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发表时间：
2003-06-01
期刊：
影响因子：
3.8
通讯作者：
Chance, B
中科院分区：
文献类型：
--
作者：
Intes, X;Ripoll, J;Chance, B
我们使用连续波扩散光学断层扫描仪研究乳腺肿瘤对非靶向造影剂的摄取。该仪器在近红外光谱窗口中工作，采用16个光源和16个探测器，在肿瘤乳腺表面（冠状几何）平行收集光。在我们的方案中，外源性造影剂，吲哚菁绿色（ICG），通过团注。研究了具有三种不同病理的三种临床情况。采用二室模型分析ICG的药代动力学并进行数据预处理，并采用漫射光学断层扫描进行成像。肿瘤的定位和勾画与先验信息吻合良好。此外，不同的动力学特征观察到不同的病理。与健康组织相比，恶性病例表现出较慢的速率常数（摄取和流出）。这些结果提供了进一步的证据，ICG在乳腺肿瘤中的体内药代动力学可能是一个有用的诊断工具，用于区分良性和恶性病变。(C)2003年美国医学物理学家协会。
We investigate the uptake of a nontargeted contrast agent by breast tumors using a continuous wave diffuse optical tomography apparatus. The instrument operates in the near-infrared spectral window and employs 16 sources and 16 detectors to collect light in parallel on the surface of the tumor-bearing breast (coronal geometry). In our protocol an extrinsic contrast agent, Indocyanine Green (ICG), was injected by bolus. Three clinical scenarios with three different pathologies were investigated. A two-compartment model was used to analyze the pharmacokinetics of ICG and preprocess the data, and diffuse optical tomography was used for imaging. Localization and delineation of the tumor was achieved in good agreement with a priori information. Moreover, different dynamical features were observed for differing pathologies. The malignant cases exhibited slower rate constants (uptake and outflow) compared to healthy tissue. These results provide further evidence that in vivo pharmacokinetics of ICG in breast tumors may be a useful diagnostic tool for differentiation of benign and malignant pathologies. (C) 2003 American Association of Physicists in Medicine.