Participation in an ambulatory e-pharmacovigilance system
Participation in an ambulatory e-pharmacovigilance system
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DOI：
10.1002/pds.2006
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发表时间：
2010-09-01
影响因子：
2.6
通讯作者：
Bates, David W.
中科院分区：
文献类型：
--
作者：
Haas, Jennifer S.;Iyer, Aarthi;Bates, David W.
目的被动监测能否及时发现药物不良事件（ADEs）受到越来越多的关注。我们的目的是证明交互式语音应答系统（IVRS）的覆盖范围，系统地监测门诊患者在服用31种药物中的一种时所经历的症状，并记录我们接触特定人群的能力是否存在差异。方法在11家诊所之一接受目标药物处方的患者有资格接受横断面IVRS调查，“电子药物警戒”，如果目标药物仍列在患者的有效药物清单中，则在3个月后进行随访调查。结果902名患者参与，占接触患者的43.3%，占潜在合格患者的25.7%。经人口统计学和药物类别调整后，bb0 ~ 66岁的患者比56 ~ 65岁的患者更有可能参与（优势比1.47；95%置信区间1.19 ~ 1.81）。西班牙裔人比白人更不可能参与（0.56;0.42-0.76），低收入社区的人比高收入社区的人更不可能参与（0.69;0.58-0.82）。服用哮喘或癫痫药物的患者比服用失眠症药物的患者更有可能参与其中。在系统接触的患者中，那些处方药物是勃起功能障碍和戒烟的可能性较小，而那些处方癫痫药物的患者更有可能参与。结论：IVRS技术可用于对广泛的患者进行动态电子药物警戒，特别是可能具有ade特别风险的老年人。版权所有John Wiley & Sons， Ltd。
Purpose There is growing concern about whether passive surveillance can detect adverse drug events (ADEs). Our objective was to demonstrate the reach of an interactive voice response system (IVRS) to systematically monitor symptoms experienced by ambulatory patients prescribed one of 31 medications, and to document whether there were differences in our ability to contact certain populations.Methods Patients receiving a prescription for a target medication at one of 11 clinics were eligible for a cross-sectional IVRS survey, "e-pharmacovigilance,'' with a follow-up survey done 3 months later if the target medication was still listed on the patient's active medication list.Results 902 patients participated, representing 43.3% of contacted and 25.7% of potentially eligible patients with a working phone. After adjustment for demographics and drug class, patients > 66 years were more likely to participate than those 56-65 years (odds ratio 1.47; 95% confidence interval 1.19-1.81). Hispanics were less likely than whites (0.56; 0.42-0.76), and those in low-income communities less likely to participate than those in high-income communities (0.69; 0.58-0.82). Patients prescribed asthma, or seizure medications were more likely to participate than those prescribed medications for insomnia. Of patients reached by the system, those prescribed medications were erectile dysfunction and smoking cessation were less likely, and those prescribed seizure medication were more likely to participate.Conclusions IVRS technology can be used to perform ambulatory e-pharmacovigilance for a broad spectrum of patients, particularly older individuals who may at particular risk for ADEs. Copyright (C) 2010 John Wiley & Sons, Ltd.