T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?
T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?
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DOI：
10.1016/j.it.2009.09.003
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发表时间：
2010-01
影响因子：
16.8
通讯作者：
Henkel JS
中科院分区：
文献类型：
--
作者：
Appel SH;Beers DR;Henkel JS
Neuroinflammation, a pathological hallmark in Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), is characterized by activated microglia and infiltrating T cells at sites of neuronal injury. In PD and ALS, neurons do not die alone; neuronal injury is non-cell-autonomous and depends on a well-orchestrated dialogue in which neuronally secreted misfolded proteins activate microglia and initiate a self-propagating cycle of neurotoxicity. Diverse populations and phenotypes of CD4+ T cells crosstalk with microglia, and depending on their activation status, may influence this dialogue and promote either neuroprotection or neurotoxicity. A greater understanding of the T cell population mediating these effects as well as the molecular signals involved should provide targets for neuroprotective immunomodulation to treat these devastating neurodegenerative diseases.
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