Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults:: the EORTC 22845 randomised trial
Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults:: the EORTC 22845 randomised trial
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DOI：
10.1016/s0140-6736(05)67070-5
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发表时间：
2005-09-17
期刊：
影响因子：
168.9
通讯作者：
Karim, ABMF
中科院分区：
文献类型：
--
作者：
van den Bent, MJ;Afra, D;Karim, ABMF
低级别胶质瘤术后的“观望”和放射治疗的政策定义不明确。20世纪80年代中期的一次试验确定了辐射剂量。1986年，EORTC放射治疗和脑肿瘤组启动了一项前瞻性试验，以比较早期放射治疗与延迟放射治疗。已报告中期分析。我们现在提出的长期result.Methods手术后，来自欧洲24个中心的患者被随机分配到早期放疗的54戈伊的分数为1.8戈伊或延迟放疗，直到时间的进展（对照组）。低级别星形细胞瘤、少突胶质细胞瘤、混合性少突星形细胞瘤和未完全切除的毛细胞性星形细胞瘤患者，WHO体能状态评分为0-2，符合入选条件。分析采用意向治疗，主要终点为总体和无进展生存率。结果157例患者接受早期放疗，157例为对照组。早期放疗组的中位无进展生存期为5.3年，对照组为3.4年（风险比0.59，95%CI 0.45-0.77; p
Background Postoperative policies of "wait-and-see" and radiotherapy for low-grade glioma are poorly defined. A trial in the mid 1980s established the radiation dose. In 1986 the EORTC Radiotherapy and Brain Tumor Groups initiated a prospective trial to compare early radiotherapy with delayed radiotherapy. An interim analysis has been reported. We now present the long-term results.Methods After surgery, patients from 24 centres across Europe were randomly assigned to either early radiotherapy of 54 Gy in fractions of 1.8 Gy or deferred radiotherapy until the time of progression (control group). Patients with low-grade astrocytoma, oligodendroglioma, mixed oligoastrocytoma, and incompletely resected pilocytic astrocytoma, with a WHO performance status 0-2 were eligible. Analysis was by intention to treat, and primary endpoints were overall and progression-free survival.Findings 157 patients were assigned early radiotherapy, and 157 control. Median progression-free survival was 5.3 years in the early radiotherapy group and 3.4 years in the control group (hazard ratio 0.59, 95% CI 0.45-0.77; p