Alcohol intake and incidence of type 2 diabetes in men
Alcohol intake and incidence of type 2 diabetes in men
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DOI：
10.2337/diacare.23.1.18
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发表时间：
2000-01-01
期刊：
影响因子：
16.2
通讯作者：
Mitchell, TL
中科院分区：
文献类型：
--
作者：
Wei, M;Kampert, JB;Mitchell, TL
目的 - 评估酒精摄入量与 2 型糖尿病发病率之间的关系。 研究设计和方法 - 这项前瞻性研究纳入了 8,663 名男性，他们至少通过两次体检测量了空腹血糖。根据酒精摄入量，酒精摄入量被分为五组：不饮酒者和饮酒者的四分位数（Qs）。 2 型糖尿病按照 1997 年美国糖尿病协会标准进行诊断。 结果 - 在 52,588 人年的随访中，有 149 例 2 型糖尿病病例。酒精摄入量与糖尿病之间存在 U 形关联，第二季度糖尿病发病率最低（61.9-122.7 克/周）。与第二季度相比，第三季度和第四季度的男性患糖尿病的风险分别为 2.2 倍（95% CI 1.2-3.9，P = 0.01）和 2.4 倍（1.4-4.4，P < 0.01），而不饮酒者和第一季度的男性患糖尿病的风险分别为 1.8 倍（1.0-3.3，P < 0.05）和 1.4 倍。 (0.7-2.6, P = 0.34) 患糖尿病的风险分别较高。在调整年龄、空腹血糖、吸烟、BMI、血压、血清甘油三酯浓度、心肺健康、高密度脂蛋白胆固醇、腰围和父母糖尿病后，这些关联仍然存在。结论——我们观察到，与报告适度饮酒的男性相比，不饮酒者和饮酒量高的男性患 2 型糖尿病的风险较高。酒精摄入量高的男性如果少喝酒，可能能够降低患 2 型糖尿病的风险。
OBJECTIVE- To evaluate the relation between alcohol intake and incidence of type 2 diabetes.RESEARCH DESIGN AND METHODS- This prospective study included 8,663 men with fasting plasma glucose measurements from at least two medical examinations. Alcohol intake was classified into five groups: nondrinkers and four quartiles (Qs) of drinkers according to the amount of alcohol intake. Type 2 diabetes was diagnosed by 1997 American Diabetes Association criteria.RESULTS- There were 149 incident cases of type 2 diabetes during 52,588 person-years of follow-up. There was a U-shaped association between alcohol intake and diabetes, with the lowest incidence of diabetes at Q2 (61.9-122.7 g/week). As compared with Q2, men in Q3 and Q4 had a 2.2- (95% CI 1.2-3.9, P = 0.01) and 2.4-fold (1.4-4.4, P < 0.01) risk of developing diabetes, while nondrinkers and men in Q1 had 1.8- (1.0-3.3, P < 0.05) and 1.4-fold (0.7-2.6, P = 0.34) higher risk of diabetes, respectively. These associations persisted after adjustment for age, fasting plasma glucose, smoking, BMI, blood pressure, serum triglyceride concentration, cardiorespiratory fitness, HDL cholesterol, waist circumference, and parental diabetes.CONCLUSIONS- We observed an elevated risk of developing type 2 diabetes in nondrinkers and men with high alcohol intakes, when compared with men who reported moderate alcohol intake. Men with a high alcohol intake may be able to reduce their risk of developing type 2 diabetes if they drink less.