The effects of neonatal amygdala or hippocampus lesions on adult social behavior.
The effects of neonatal amygdala or hippocampus lesions on adult social behavior.
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DOI：
10.1016/j.bbr.2016.11.052
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发表时间：
2017-03-30
影响因子：
2.7
通讯作者：
Amaral DG
中科院分区：
文献类型：
--
作者：
Bliss-Moreau E;Moadab G;Santistevan A;Amaral DG
本报告详细介绍了对一组成年恒河猴的社会行为进行纵向评估的最后阶段，这些恒河猴在两周龄时接受了双侧杏仁核或海马神经毒性损伤或假手术。结果与之前的研究进行了比较，在这些研究中，成年动物接受了杏仁核损伤，并以类似的方式进行了测试。当动物 7 至 8 岁时，对四个新的互动伙伴进行了社会测试。实验动物在两种条件下与两名雄性和两名雌性伴侣进行互动——一种是身体接触受到限制（受限的社交接触条件），另一种是身体接触不受限制（不受限制的社交接触条件）。在各种条件和互动伙伴中，病变条件对社交互动的频率或持续时间没有显着影响。作为一个群体，海马体受损的动物在社交接触受限的情况下产生了最多数量的交流信号。杏仁核受损的动物产生更频繁的与压力相关的行为，并且探索性更少。杏仁核和海马体受损的动物比对照动物表现出更多的刻板印象。观察到行为顺序中基于病变的微妙差异。这些发现表明，当杏仁核损伤发生在生命早期而不是成年时，成人社会行为的改变就不那么明显。
The present report details the final phase of a longitudinal evaluation of the social behavior in a cohort of adult rhesus monkeys that received bilateral neurotoxic lesions of the amygdala or hippocampus, or sham operations at 2 weeks of age. Results were compared to previous studies in which adult animals received amygdala lesions and were tested in a similar fashion. Social testing with four novel interaction partners occurred when the animals were between 7 and 8 years of age. Experimental animals interacted with two male and two female partners in two conditions — one in which physical access was restricted (the constrained social access condition) and a second in which physical access was unrestricted (the unconstrained social access condition). Across conditions and interaction partners, there were no significant effects of lesion condition on the frequency or duration of social interactions. As a group, the hippocampus-lesioned animals generated the greatest number of communicative signals during the constrained social access condition. Amygdala-lesioned animals generated more frequent stress-related behaviors and were less exploratory. Amygdala and hippocampus-lesioned animals demonstrated greater numbers of stereotypies than control animals. Subtle, lesion-based differences in the sequencing of behaviors were observed. These findings suggest that alterations of adult social behavior are much less prominent when damage to the amygdala occurs early in life rather than in adulthood.