Erianin inhibits the oncogenic properties of hepatocellular carcinoma via inducing DNA damage and aberrant mitosis
Erianin inhibits the oncogenic properties of hepatocellular carcinoma via inducing DNA damage and aberrant mitosis
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毛兰素通过诱导 DNA 损伤和异常有丝分裂抑制肝细胞癌的致癌特性
DOI：
10.1016/j.bcp.2020.114266
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发表时间：
2020-12-01
影响因子：
5.8
通讯作者：
Chen, Jianxiang
中科院分区：
文献类型：
--
作者：
Dong, Heng;Wang, Menglan;Chen, Jianxiang
天然化合物已被证实是治疗肝细胞癌等难治性癌症的最可行的解决方案之一。石榴素是一种从金针石斛中分离出来的天然联苯类化合物，最近被发现具有抗癌活性。然而，Erianin在肝细胞癌中的作用和分子机制尚不清楚。本研究从抑制细胞增殖、诱导细胞凋亡相关死亡和抑制致瘤性等方面评价了茜草素对人肝癌细胞的作用。此外，还发现Erianin可以造成DNA不可修复的损伤，诱导G2/M期停滞，并解除对有丝分裂调节的调节。此外，还观察到Erianin诱导的许多DNA损伤的细胞可以克服G2/M期停滞，进入有丝分裂，导致异常的有丝分裂，随后发生有丝分裂灾难和与凋亡相关的细胞死亡。本研究证实了茜草素可作为一种潜在的抗肿瘤药物用于肝癌的临床治疗。
Natural compounds have been confirmed as one of the most feasible solutions for hard-to-treat cancers such as hepatocellular carcinoma (HCC). Erianin, a natural bibenzyl compound from Dendrobium chrysotoxum, has been recently discovered with anticancer property in cancer cells. However, the roles and the molecular mechanisms of erianin in HCC remain unknown. The present study evaluates the effect of erianin on human HCC cells by inhibiting cell proliferation, inducing apoptotic-related cell death and hampering tumorigenicity. Furthermore, it was found that erianin could cause irreparable DNA damage, induce G2/M arrest and deregulate mitotic regulators. It was also observed that many cells with damaged DNA induced by erianin could overcome G2/M arrest and enter mitosis, leading to abnormal mitosis, and subsequently mitotic catastrophe and apoptotic-related cell death. The present study confirmed that erianin could be a potential antitumor agent for HCC clinical treatment.