Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study
Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study
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DOI：
10.1111/j.1365-2036.2005.02673.x
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发表时间：
2005-11-01
影响因子：
7.6
通讯作者：
Ho, KY
中科院分区：
文献类型：
--
作者：
Lu, WZ;Gwee, KA;Ho, KY
背景资料：褪黑激素参与胃肠运动和感觉的调节。目的：探讨褪黑激素对肠易激综合征（IBS）的潜在治疗作用。17名符合IBS罗马II标准的女性患者随机接受褪黑激素3 mg单次给药或相同外观的安慰剂1 mg单次给药8周，随后是4周的清除期，并以相反的顺序再用安慰剂或褪黑激素8周。三个有效的问卷调查-GI症状，睡眠问卷和医院焦虑和抑郁量表-被用来评估症状的严重程度，并计算IBS，睡眠和焦虑/抑郁评分，分别。褪黑激素治疗后平均IBS评分的改善（3.9 +/- 2.6）显著大于安慰剂治疗（1.3 +/- 4.0，P = 0.037）。缓解率百分比（定义为IBS症状获得轻度至极好改善的受试者百分比）在褪黑激素治疗组中也更高（88% vs. 47%，P = 0.04）。平均睡眠，焦虑和抑郁评分的变化与褪黑激素或安慰剂treatment.Conclusions：褪黑激素是一种很有前途的治疗IBS的药物。其治疗效果与其对睡眠、焦虑或抑郁的影响无关。
Background: Melatonin is involved in the regulation of gastrointestinal motility and sensation.Aim: To determine the potential therapeutic effects of melatonin in irritable bowel syndrome (IBS).Method: Seventeen female patients satisfying the Rome II criteria for IBS were randomized to receive either melatonin 3 mg nocte or identically appearing placebo 1 nocte for 8 weeks, followed by a 4-week washout period and placebo or melatonin in the reverse order for another 8 weeks. Three validated questionnaires - the GI symptom, the sleep questionnaires and the Hospital Anxiety and Depression Scale - were used to assess symptom severity and to compute the IBS, sleep and anxiety/depression scores, respectively.Results: Improvements in mean IBS scores were significantly greater after treatment with melatonin (3.9 +/- 2.6) than with placebo (1.3 +/- 4.0, P = 0.037). Percent response rate, defined as percentage of subjects achieving mild-to-excellent improvement in IBS symptoms, was also greater in the melatonin-treated arm (88% vs. 47%, P = 0.04). The changes in mean sleep, anxiety, and depression scores were similar with either melatonin or placebo treatment.Conclusions: Melatonin is a promising therapeutic agent for IBS. Its therapeutic effect is independent of its effects on sleep, anxiety or depression.