Newer antidepressants for hot flashes-should their efficacy still be up for debate?
Newer antidepressants for hot flashes-should their efficacy still be up for debate?
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DOI：
10.1097/gme.0b013e31817dfd2b
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发表时间：
2009-01-01
影响因子：
2.7
通讯作者：
Wolf, Sherry
中科院分区：
文献类型：
--
作者：
Loprinzi, Charles L.;Barton, Debra L.;Wolf, Sherry
目的：临床试验表明，新型抗抑郁药可以减少潮热，但效果不如激素。尽管如此，最近发表的荟萃分析和随后的社论对新型抗抑郁药治疗潮热的效用提出了质疑。对新型抗抑郁药对潮热缺乏疗效的担忧主要基于两项安慰剂对照双盲试验的结果，一项评估文拉法辛，另一项单独评估氟西汀和西酞普兰。这两项研究已多次被提出，作为新的抗抑郁药并未明确证明可以减少潮热的证据。 设计：从这两项评估第二代抗抑郁药治疗潮热的随机、安慰剂对照试验中获得了原始数据。这些数据和随后的研究结论在其他已发表的关于使用新型抗抑郁药治疗潮热的试验数据的背景下进行了评估和讨论。结果：对这两项试验的原始数据的检查表明，两者都没有采用基线期的闪蒸测定来计算相对于基线随时间的变化。结论：认识到这两项试验不能用于观察潮热频率或分数相对于基线的变化，这限制了它们向关于使用新型抗抑郁药治疗潮热的功效文献提供信息的能力。减少潮热。
Objective: Newer antidepressants have been shown in clinical trials to reduce hot flashes, although not as well as do hormones. Nonetheless, a recently published meta-analysis and subsequent editorial raised doubts with regard to the utility of newer antidepressants for treating hot flashes. Concerns about the lack of efficacy of newer antidepressants on hot flashes were based in large part oil results of two placebo-controlled, double-blind trials, one evaluating venlafaxine and the other individually evaluating both fluoxetine and citalopram. These two studies have repeatedly been Put forward as evidence that newer antidepressants are not definitively proven to reduce hot flashes.Design: Raw data from these two randomized, placebo-controlled trials evaluating second-generation anti depressants for]lot flashes were obtained. These data and Subsequent study conclusions are evaluated and discussed in the context of other published trial data regarding the use of newer antidepressants for treating hot flashes.Results: Examination of the raw data from these two trials revealed that neither employed a baseline period of]lot flash determination against which to calculate changes over time from baseline.Conclusions: Recognition that these two trials cannot be used to look at hot flash frequency or score changes from baseline limits their ability to inform the efficacy literature about the use of newer antidepressants for hot flash reduction.