Prevalence of AD among whites - A summary by levels of severity
Prevalence of AD among whites - A summary by levels of severity
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DOI：
10.1212/wnl.55.2.198
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发表时间：
2000-07-25
期刊：
影响因子：
9.9
通讯作者：
Keller, DM
中科院分区：
文献类型：
--
作者：
Hy, LX;Keller, DM
目的：使用四种基于严重程度的病例定义来确定年龄和性别特异性AD的白人患病率：诊断为至少可疑AD的人，诊断为至少轻度AD的人，诊断为中度或重度AD的人，诊断为重度AD的人。方法：汇总来自欧洲和北美的21项研究的数据。结果：从经验上看，来自东波士顿的一项研究是一个异常值。应用于1996年的美国人口，所获得的估计值得出的患病率为170万至190万例，具体取决于是否排除或包括异常值研究。结论：考虑到疾病严重程度，白人人群对AD患病率的估计比通常认为的更为一致。通过在病例定义中纳入疾病严重程度，报告发病率的差异大大减少。东波士顿研究的异常状态似乎是由于使用了与其他20项研究不同的AD定义。对这些估计与400万例的共同估计之间的差异的其他解释进行了讨论。
Objective: To determine age-and sex-specific AD prevalence rates for whites using each of four severity-based definitions of a case: a person diagnosed as having at least questionable AD, one diagnosed as having at least mild AD, one diagnosed as having moderate or severe AD, and one diagnosed as having severe AD. Methods: Data fi om 21 studies of Europeans and North Americans were pooled. Results: Empirically, one study, from East Boston, is an outlier. Applied to the US population of 1996, the obtained estimates yield a prevalence of 1.7 to 1.9 million cases, depending on whether the outlier study is excluded or included. Conclusions:With disease severity taken into account, estimates of AD prevalence from white populations are more consistent than is usually acknowledged. By including disease severity in the case definition, variations in reported rates are much reduced. The outlier status of the East Boston study appears to result from the use of a definition of AD that differs from that used in the other 20 studies. Alternative explanations of the discrepancy between these estimates and the common estimate of 4 million cases are discussed.