MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
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DOI：
10.1038/ng765
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发表时间：
2002-01-01
期刊：
影响因子：
30.8
通讯作者：
Korsmeyer, SJ
中科院分区：
文献类型：
--
作者：
Armstrong, SA;Staunton, JE;Korsmeyer, SJ
携带涉及混合谱系白血病基因（MLL、ALL 1、HRX）的染色体易位的急性淋巴细胞白血病预后特别差。在这里，我们表明，他们有一个特点，高度不同的基因表达谱，这是符合早期造血祖细胞表达选择多谱系标记和个别HOX基因。聚类算法显示，MLL易位的淋巴细胞白血病可以清楚地从传统的急性淋巴细胞白血病和急性髓细胞白血病中分离出来。我们提出，它们构成了一种独特的疾病，在这里表示为MLL，并表明基因表达的差异是强大的，足以正确地将白血病分类为MLL，急性淋巴细胞白血病或急性髓细胞白血病。确定MLL是一个独特的实体是至关重要的，因为它要求检查选择性表达的基因，以获得迫切需要的分子靶点。
Acute lymphoblastic leukemias carrying a chromosomal translocation involving the mixed-lineage leukemia gene (MLL, ALL1, HRX) have a particularly poor prognosis. Here we show that they have a characteristic, highly distinct gene expression profile that is consistent with an early hematopoietic progenitor expressing select multilineage markers and individual HOX genes. Clustering algorithms reveal that lymphoblastic leukemias with MLL translocations can clearly be separated from conventional acute lymphoblastic and acute myelogenous leukemias. We propose that they constitute a distinct disease, denoted here as MLL, and show that the differences in gene expression are robust enough to classify leukemias correctly as MLL, acute lymphoblastic leukemia or acute myelogenous leukemia. Establishing that MLL is a unique entity is critical, as it mandates the examination of selectively expressed genes for urgently needed molecular targets.