Possible prediction of underlying lymphoma by high sIL-2R/ferritin ratio in hemophagocytic syndrome
Possible prediction of underlying lymphoma by high sIL-2R/ferritin ratio in hemophagocytic syndrome
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DOI：
10.1007/s00277-011-1239-7
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发表时间：
2012-01-01
影响因子：
3.5
通讯作者：
Tabata, Rie
中科院分区：
文献类型：
--
作者：
Tabata, Chiharu;Tabata, Rie
在某些情况下，由于缺乏肿块形成和没有明显的淋巴结肿大，淋巴瘤相关噬血细胞综合征（LAHS）的诊断是困难的，这导致疾病进展，预后不良。因此，在继发性噬血细胞综合征（HPS）的诊断中，需要潜在恶性淋巴瘤的标志物。我们回顾了110例日本患者，其中包括57例LAHS和53例良性疾病相关HPS患者，并证明LAHS患者的血清sIL-2 R水平和sIL-2 R/铁蛋白比值均高于良性疾病相关HPS患者。大多数LAHS患者表现出高值的两个指数。两项指标均高的患者对LAHS的阳性预测值为95.6%。另一方面，两项指标均低的患者对良性疾病相关HPS的预测值为92.1%。我们建议血清sIL-2 R/铁蛋白比值作为一个新的有用的指标，预测潜在的恶性淋巴瘤HPS患者。
In some instances, because of the lack of mass formation and the absence of prominent lymph node enlargement, diagnosis of lymphoma-associated hemophagocytic syndrome (LAHS) is difficult, which results in the development of progressive disease with unfavorable prognosis. Therefore, in the diagnosis of secondary hemophagocytic syndrome (HPS), markers for underlying malignant lymphoma are required. We reviewed 110 Japanese patients, including 57 LAHS cases and 53 benign disease-associated HPS cases, and demonstrated that the values of the serum sIL-2R level and sIL-2R/ferritin ratio in LAHS patients were both statistically higher than those of patients with benign disease-associated HPS. Most LAHS patients showed high values of both indices. The positive predictive value of patients showing high values of both indices for LAHS was 95.6%. On the other hand, the predictive value of patients showing low values of both indices for benign disease-associated HPS was 92.1%. We propose serum sIL-2R/ferritin ratio as a novel useful marker for predicting underlying malignant lymphoma in HPS patients.