MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer.
MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer.
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DOI：
10.18632/oncotarget.6390
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发表时间：
2016-02-09
期刊：
影响因子：
--
通讯作者：
Lothe RA
中科院分区：
文献类型：
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作者：
Cekaite L;Eide PW;Lind GE;Skotheim RI;Lothe RA
基因表达部分由microRNAs（miRNAs）调控。本文综述了miRNAs在结直肠癌（CRC）中的作用、miRNAs自身的调控机制以及miRNAs作为生物标志物的潜力。尽管已经研究了来自CRC患者的数千个组织样品和体液的miRNA的生物标志物潜力（在综合表格中呈现了>160篇论文），但是没有单一的miRNA或miRNA表达特征用于这种疾病的临床用途。超过500个miRNA靶对已被确定在CRC中，我们讨论这些调控节点如何互连和影响CRC进展中的信号通路。
Gene expression is in part regulated by microRNAs (miRNAs). This review summarizes the current knowledge of miRNAs in colorectal cancer (CRC); their role as growth regulators, the mechanisms that regulate the miRNAs themselves and the potential of miRNAs as biomarkers. Although thousands of tissue samples and bodily fluids from CRC patients have been investigated for biomarker potential of miRNAs (>160 papers presented in a comprehensive tables), none single miRNA nor miRNA expression signatures are in clinical use for this disease. More than 500 miRNA-target pairs have been identified in CRC and we discuss how these regulatory nodes interconnect and affect signaling pathways in CRC progression.