GLCCI1 Variation Is Associated with Asthma Susceptibility and Inhaled Corticosteroid Response in a Chinese Han Population
GLCCI1 Variation Is Associated with Asthma Susceptibility and Inhaled Corticosteroid Response in a Chinese Han Population
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GLCCI1 变异与中国汉族人群的哮喘易感性和吸入皮质类固醇反应相关
DOI：
10.1016/j.arcmed.2016.04.005
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发表时间：
2016-02-01
影响因子：
7.7
通讯作者：
Feng, Juntao
中科院分区：
文献类型：
--
作者：
Hu, Chengping;Xun, Qiufen;Feng, Juntao
背景和目标。GLCCI 1变异与非西班牙裔白色哮喘受试者对糖皮质激素治疗的反应相关。然而，也有其他相关研究与这一发现不一致。在这项研究中，我们的目的是评估GLCCI 1变异与哮喘易感性和吸入皮质类固醇（ICS）反应的关系。我们对182名哮喘患者和180名健康对照者的GLCCI 1基因24个单核苷酸多态性进行了基因分型。此外，我们分析了30例轻中度哮喘患者中GLCCI 1变异与ICS反应的关系。rs 11976862纯合子突变基因型GG名义上与哮喘风险增加相关（OR = 2.435，95%CI：1.221-4.854，p = 0.01148，p（corr）= 0.0127）。rs37972、rs37973和rs 11976862的隐性模型显示，罕见等位基因与氟替卡松治疗12周后FEV 1改善较少相关（分别为p = 0.004、p = 0.009和p = 0.039）。哮喘组GLCCI 1 mRNA表达水平明显低于健康对照组（0.037663 ± 0.0216833 vs. 0.046352 ± 0.0235812，p = 0.000）。对于哮喘患者，在氟替卡松治疗12周后，GLCCI 1 mRNA表达水平显著增加（0.067641 +/- 0.031547 vs. 0.030048 +/- 0.014613，p = 0.000）。在隐性模型中，GLCCI 1 mRNA表达的变化与rs37973和rs 11976862显著相关（分别为p = 0.014和p = 0.033）。GLCCI 1变异与中国汉族成人哮喘易感性和ICS反应相关GLCCI 1变异可能通过调节GLCCI 1表达而影响ICS反应。(C)2016年IMSS。爱思唯尔公司出版
Background and Aims. GLCCI1 variations are found to be associated with response to glucocorticoid therapy in non-Hispanic white subjects with asthma. However, there are also other relevant studies that were not consistent with this finding. In this study we aimed to evaluate the association of GLCCI1 variations with asthma susceptibility and inhaled corticosteroid (ICS) response in a Chinese adult Han population.Methods. We genotyped 24 single nucleotide polymorphisms of GLCCI1 in 182 asthmatic patients and 180 healthy controls. Furthermore, we analyzed the association of GLCCI1 variations with ICS response in 30 mild-to-moderate asthmatics.Results. rs11976862 homozygote mutant genotype GG was nominally associated with increased asthma risk (OR = 2.435, 95% CI: 1.221-4.854, p = 0.01148, p(corr) = 0.0127). Recessive model of rs37972, rs37973 and rs11976862 showed that the rare alleles were correlated with less improvement in FEV1 after fluticasone treatment for 12 weeks (p = 0.004, p = 0.009 and p = 0.039, respectively). The GLCCI1 mRNA expression level decreased obviously in asthmatics than in healthy controls (0.037663 +/- 0.0216833 vs. 0.046352 +/- 0.0235812, p = 0.000). For asthmatics, GLCCI1 mRNA expression level significantly increased after fluticasone treatment for 12 weeks (0.067641 +/- 0.031547 vs. 0.030048 +/- 0.014613, p = 0.000). Moreover, changes of GLCCI1 mRNA expression were significantly related with rs37973 and rs11976862 in a recessive model (p = 0.014 and p = 0.033, respectively).Conclusions. GLCCI1 variations are associated with asthma susceptibility and ICS response in a Chinese Han adult population. GLCCI1 variations may affect ICS response by modulating GLCCI1 expression. (C) 2016 IMSS. Published by Elsevier Inc.