Real-time in vivo optical coherence microscopy
Real-time in vivo optical coherence microscopy
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实时体内光学相干显微镜
DOI：
10.1109/cleo.2001.947875
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
J. Izatt
中科院分区：
文献类型：
--
作者：
V. Westphal;Hsing;J. Izatt
只提供摘要形式。体内共聚焦显微镜已经被提出，并被证明是一种强大的无创成像工具，由于其强大的轴向分辨力，可以对大量生物样品进行光学切片。根据数值孔径（NA），轴向和横向分辨率为几微米是可获得的。然而，在像皮肤这样的高度散射组织中，由于样品的非聚焦区域产生的多个散射光子，成像的最大深度被限制在几百微米。光学相干显微镜（OCM）是共聚焦显微镜和光学相干层析成像（OCT）的结合。在OCM中，OCT的相干门与共聚焦显微镜的共聚焦门重叠，以增加对多重散射光子的抑制，从而扩大可用深度范围。
Summary form only given. In-vivo confocal microscopy has been proposed/sup 1/ and demonstrated as a powerful tool for noninvasive imaging permitting optical sectioning in bulk biological samples due to its strong axial discrimination. Depending on the numerical aperture (NA), axial and lateral resolutions of several micrometers are obtainable. The maximal depth of imaging is limited to several hundred microns in highly scattering tissues such as the skin, however, by multiple scattered photons arising from out-of-focus-regions of the sample. Optical coherence microscopy (OCM) is a combination of confocal microscopy and optical coherence tomography (OCT). In OCM, the coherence gate of OCT is overlapped with the confocal gate of confocal microscopy to provide increased rejection of multiply scattered photons and therefore extend the usable depth range.