Expression of CD133 in Synovial Sarcoma
Expression of CD133 in Synovial Sarcoma
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DOI：
10.1097/pai.0b013e3181b77451
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发表时间：
2010-03-01
影响因子：
1.6
通讯作者：
Nielsen, Torsten
中科院分区：
文献类型：
--
作者：
Terry, Jefferson;Nielsen, Torsten
滑膜肉瘤是一种移位定义的软组织肿瘤，组织来源不明，对全身治疗有相当大的抵抗力，预后不良，可能涉及癌症干细胞。最近的研究表明，滑膜肉瘤起源于原始的祖细胞类型，并表明滑膜肉瘤包含具有增强致瘤潜能的亚群；然而，关于滑膜肉瘤中的癌症干细胞样细胞知之甚少。组织学和基因表达研究已经报道了滑膜肉瘤的特征，这些特征使人联想到神经发育，这表明神经癌干细胞样细胞标记物，如CD133，可能标记滑膜肉瘤中的癌症干细胞样细胞，从而允许进一步的表征。在此，我们检测了CD133在滑膜肉瘤肿瘤组织和滑膜肉瘤细胞系中的免疫组织化学表达。CD133表达细胞亚群在所有原发滑膜肉瘤(5/5)和滑膜肉瘤细胞系(3/3)中均有表达。组织学上CD133阳性细胞散在分布，似有树突状突起。本研究首次证实了CD133表达细胞在滑膜肉瘤中的存在，并验证了3个滑膜肉瘤细胞系作为进一步研究CD133+亚群的模型。CD133的表达与肿瘤干细胞的关系提示，表达CD133的滑膜肉瘤细胞可能代表滑膜肉瘤中的肿瘤干细胞样细胞，这对了解滑膜肉瘤的发病机制和开发有效的治疗方法具有重要意义。
The development of synovial sarcoma, a translocationally defined soft tissue tumor of unknown histogenesis with considerable resistance to systemic therapy and a poor prognosis, may involve cancer stem-like cells. Recent studies suggest that synovial sarcoma arises from a primitive progenitor-type cell and have shown that synovial sarcomas contain subpopulations with enhanced tumorigenic potential; however, little is known about cancer stem-like cells in synovial sarcoma. Histologic and gene expression studies have reported features of synovial sarcoma that are reminiscent of neural development, suggesting that a neural cancer stem-like cell marker, such as CD133, may mark cancer stem-like cells in synovial sarcoma, allowing for further characterization. Here, the immunohistochemical expression of CD133 in primary synovial sarcoma tumor tissue and synovial sarcoma cell lines is determined. Subpopulations of CD133 expressing cells are present in all primary synovial sarcomas (5/5) and synovial sarcoma cell lines (3/3) examined. Histologically, CD133 positive cells are dispersed and seem to have dendritic processes. This study demonstrates the presence of CD133 expressing cells in synovial sarcoma for the first time and validates 3 synovial sarcoma cell lines as models for further study of the CD133+ subpopulation. The relationship between CD133 expression and cancer stem-like cells suggests that CD133 expressing synovial sarcoma cells may represent cancer stem-like cells in synovial sarcoma, which has significant implications for understanding the pathogenesis of this tumor and developing effective therapies.