Episodic fluctuations of serum gonadotropins in pre- and post-pubertal girls and boys.
Episodic fluctuations of serum gonadotropins in pre- and post-pubertal girls and boys.
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青春期前后女孩和男孩血清促性腺激素的间歇性波动。
DOI：
10.1210/jcem-45-2-307
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
S. Frasier
中科院分区：
文献类型：
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作者：
R. Penny;N. O. Olambiwonnu;S. Frasier
测定了7名9.5 ~ 16.5岁的正常女孩和8名9.0 ~ 16.8岁的正常男孩在4小时内每隔15分钟采集的血清中LH和FSH的浓度。在所有受试者中均发现黄体生成素分泌的偶发性模式。在发作次数（每4小时3.0 +/- 0.6 vs 3.0 +/- 0.0）、LH绝对增加（2.6 +/- 1.1 vs 2.4 +/- 1.0 mIU / ml）或“LH表观半衰期”（64.3 +/- 20.8 vs 76.1 +/- 23.4 min）方面，女孩和男孩之间没有显著差异（P > 0.1）。LH分泌期平均绝对增加与每4 h平均LH浓度相关（R = 0.89, P < 0.005）， LH分泌期平均增加百分比与平均LH表观半衰期呈显著负相关（R = -0.52）。FSH也有轻微波动。在女孩和男孩中，两种促性腺激素的平均浓度随着青春期的推进而增加。LH浓度的增加是由于分泌发作幅度的增加而不是发作次数的增加。FSH浓度的增加反映了整个采样期间的持续升高。
The concentrations of LH and FSH were determined in serum samples obtained at 15 min intervals during a 4 h period from seven normal girls, 9.5-16.5 years of age, and eight normal boys, 9.0-16.8 years of age. An episodic pattern of LH secretion was found in all subjects. There was no significant (P greater than 0.1) difference between girls and boys as to number of episodes (3.0 +/- 0.6 vs. 3.0 +/- 0.0 per 4 h), absolute LH increase (2.6 +/- 1.1 vs. 2.4 +/- 1.0 mIU per ml) or "apparent LH half-life" (64.3 +/- 20.8 vs. 76.1 +/- 23.4 min). Mean absolute increase during secretory episodes correlated (R = 0.89, P less than 0.005) with the mean LH concentration per 4 h, and a significant (P less than 0.025) inverse correlation (R = -0.52) was found between the mean per cent increment of the LH secretory episode and the mean "apparent LH half-life." Minor fluctuations of FSH were also observed. In girls and boys, the mean concentration of both gonadotropins increased with advancing puberty. The increase in LH concentration was due to an increase in the amplitude of secretory episodes rather than to an increase in the number of episodes. The increase in FSH concentration reflected a consistent elevation throughout the period of sampling.