Association of physical activity and sitting time with incident colorectal cancer in postmenopausal women.
Association of physical activity and sitting time with incident colorectal cancer in postmenopausal women.
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DOI：
10.1097/cej.0000000000000351
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发表时间：
2018-07
期刊：
影响因子：
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通讯作者：
Chomistek AK
中科院分区：
文献类型：
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作者：
Gorczyca AM;Eaton CB;LaMonte MJ;Garcia DO;Johnston JD;He K;Bidulescu A;Goodman D;Groessl E;Lane D;Stefanick ML;Newcomb P;Mouton C;Chomistek AK
流行病学研究发现，体力活动（PA）与结直肠癌（CRC）风险降低有关。最近的研究发现，坐着时间（ST）越长，CRC风险越高;然而，许多研究没有将PA作为潜在的混杂因素。本项目的目的是调查ST和PA与结肠直肠癌（特别是结肠癌和直肠癌）发病风险的独立和联合相关性。妇女健康倡议观察性研究的参与者（n = 74，870），50-79岁，基线、第3年和第6年自我报告ST和PA。CRC事件是主要结局;结肠癌和直肠癌是次要结局，由中心裁定。在13年的随访中，记录了1，145例CRC事件。在较高的ST（≥10 vs <5小时/天）与CRC（趋势p =0.04）和结肠癌（趋势p =0.05）之间发现了年龄校正的正相关性;然而，这些相关性减弱，在多变量校正模型中不再显著。与非活动女性（≤1.7 MET小时/周）相比，高PA（> 20 MET小时/周）组的CRC多变量风险为0.81（95% CI：0.66 - 1.00;趋势p为0.04）。与不活动的高ST妇女（≥ 10小时/天）相比，无论ST水平如何，PA较高的多变量CRC风险有降低的趋势（交互作用=0.64）。我们观察到休闲时间PA与CRC风险之间呈负相关，特别是直肠癌。在多变量模型中ST和CRC之间没有关联。
Findings from epidemiological studies have found physical activity (PA) is associated with lower colorectal cancer (CRC) risk. Recent studies have found an increased CRC risk with higher sitting time (ST); however, many studies did not include PA as a potential confounder. The objective of this project was to investigate the independent and joint associations of ST and PA with risk of incident colorectal cancer, specifically colon and rectal cancer. Participants in the Women’s Health Initiative Observational Study (n = 74,870), 50–79 years of age self-reported ST and PA at baseline, year 3 and year 6. Incident CRC was the primary outcome; colon and rectal cancers were secondary outcomes which were centrally adjudicated. Over a 13-year follow-up, 1,145 incident cases of CRC were documented. A positive age-adjusted association was found between higher ST (≥10 versus <5 hrs/day) and CRC (p for trend=0.04) and colon cancer (p for trend=0.05); however, these associations were attenuated and no longer significant in multivariable-adjusted models. Compared to inactive women (≤1.7 MET-hrs/week), the multivariable risk of CRC in the high PA (> 20 MET-hrs/week) group was 0.81 (95% CI: 0.66 – 1.00; p for trend 0.04). Compared to inactive women with high ST (≥ 10 hrs/d), there was a trend for reduced multivariable CRC risks with higher PA regardless of ST level (interaction=0.64) We observed an inverse association between leisure time PA and risk of CRC, particularly for rectal cancer. There was no association between ST and CRC in multivariable models.