The rat animal model for noise-induced hearing loss
The rat animal model for noise-induced hearing loss
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DOI：
10.1121/1.5132553
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发表时间：
2019-11-01
影响因子：
2.4
通讯作者：
Lobarinas, Edward
中科院分区：
文献类型：
--
作者：
Escabi, Celia D.;Frye, Mitchell D.;Lobarinas, Edward
大鼠具有良好的适应性、健壮性、生存能力和智商，是研究医学、生物、遗传和行为现象的极佳模型。大鼠的听觉系统的一般解剖学和生理学与在人类中观察到的相似，这导致它们被用于研究噪音过度暴露对哺乳动物听觉系统的影响。本文综述了研究噪声性听力损失的大鼠模型，并重点介绍了利用大鼠研究噪声性听力损失的进展，特别是与噪声剂量和不同实验噪声类型的有害影响有关的进展。除了传统的声损伤后听觉功能的丧失外，最近的发现表明，大鼠是观察噪声损伤后中枢神经系统内神经元处理变化的有用模型。此外，在研究噪声诱导的耳蜗突触时，大鼠提供了第二个动物模型，因为在大鼠模型中检测这一点的研究类似于在小鼠中观察到的一般模式。总之，这些发现证明了该动物模型的相关性，以促进作者对噪声对听力的结构、解剖、生理和知觉方面的影响的理解。(C)2019年美国声学学会。
Rats make excellent models for the study of medical, biological, genetic, and behavioral phenomena given their adaptability, robustness, survivability, and intelligence. The rat's general anatomy and physiology of the auditory system is similar to that observed in humans, and this has led to their use for investigating the effect of noise overexposure on the mammalian auditory system. The current paper provides a review of the rat model for studying noise-induced hearing loss and highlights advancements that have been made using the rat, particularly as these pertain to noise dose and the hazardous effects of different experimental noise types. In addition to the traditional loss of auditory function following acoustic trauma, recent findings have indicated the rat as a useful model in observing alterations in neuronal processing within the central nervous system following noise injury. Furthermore, the rat provides a second animal model when investigating noise-induced cochlear synaptopathy, as studies examining this in the rat model resemble the general patterns observed in mice. Together, these findings demonstrate the relevance of this animal model for furthering the authors' understanding of the effects of noise on structural, anatomical, physiological, and perceptual aspects of hearing. (C) 2019 Acoustical Society of America.