Lewy body-related α-synucleinopathy in aging
Lewy body-related α-synucleinopathy in aging
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DOI：
10.1093/jnen/63.7.742
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发表时间：
2004-07-01
影响因子：
3.2
通讯作者：
Murayama, S
中科院分区：
文献类型：
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作者：
Saito, Y;Ruberu, NN;Murayama, S
为了阐明路易小体相关的阿尔法突触核病在衰老中的意义，我们调查了1241例连续尸检病例(男性663例，女性578例)LBS的发生率。病理切片苏木精-伊红染色，抗泛素和抗α-突触核蛋白抗体。无LBS者987例，LB0期。LBI期=偶发性LBS(149例)，LB期II=LB型变性(47例)，LB期III期=无痴呆帕金森病(10例)，LB期IV=路易体痴呆(DLB型)过渡(边缘)型(25例)，LB期V=DLB型(23例)。患有LBS的患者的平均死亡年龄较大。在LB型病理上没有性别差异。对氧磷酶1基因G842A多态与男性LBII期或以上相关，提示存在性别相关的危险因素。Lb分期V期患者神经原纤维缠绕和老年斑块受累程度较高，载脂蛋白E epsilon 4的表达频率也较高。我们的发现表明，LBS与认知功能下降有关，可能是独立的，也可能是与神经原纤维缠结和老年斑协同作用的。
To clarify the significance of Lewy body (LB)-related alpha-synucleinopathy in aging, we investigated the incidence of LBs in 1,241 consecutive autopsy cases (663 males and 578 females). LB pathology was identified histologically in sections stained with hematoxylin and eosin and with anti-ubiquitin and anti-alpha-synuclein antibodies. Cases without LBs were classified as LB stage 0 (987 cases). Cases with LBs were classified as follows: LB stage I = incidental LBs (149 cases); LB stage II = LB-related degeneration without attributable clinical symptoms (47 cases); LB stage III = Parkinson disease without dementia (10 cases); LB stage IV = dementia with Lewy bodies (DLB) transitional (limbic) form (25 cases); and LB stage V = DLB neocortical form (23 cases). The average age at death was greater for those cases with LBs. There were no gender differences in the LB pathology. G842A polymorphism in the paraoxonase 1 gene was associated with men in LB stage II or above and suggests a gender-specific risk factor. LB stage V had higher stages of neurofibrillary tangle and senile plaque involvement and also had a higher frequency of apolipoprotein E epsilon4. Our findings indicate that LBs are associated with cognitive decline, either independently or synergistically with neurofibrillary tangles and senile plaques.