Effects of methylphenidate on reward strength in boys with attention-deficit hyperactivity disorder.

Effects of methylphenidate on reward strength in boys with attention-deficit hyperactivity disorder.
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哌甲酯对注意力缺陷多动障碍男孩奖励强度的影响。

DOI:
10.1097/00004583-199507000-00013
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发表时间:
1995
期刊:
Journal of the American Academy of Child and Adolescent Psychiatry.
影响因子:
--
通讯作者:
Sloane,HN
Sloane,HN
中科院分区:
--
文献类型:
--
作者:
Wilkison,PC;Kircher,JC;McMahon,WM;Sloane,HN

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目的验证注意缺陷多动障碍(ADHD)儿童中哌醋甲酯降低奖赏阈值的假设。方法采用双盲交叉设计,16名8~13岁的ADHD男孩在一次测试中服用哌醋甲酯,在另一次测试中服用安慰剂。在每种情况下,受试者都要完成一项任务,这项任务需要按下越来越多的按钮才能获得固定的金钱回报。结果在药物试验期间,多动症儿童不愿继续执行任务的“临界点”明显高于安慰剂试验。结论该结果支持了一个假设,即ADHD回报系统功能障碍假说的基础,他们表明,奖励机制可能是在广泛的任务和环境中观察到的刺激剂的治疗效果的基础。J.Am阿卡德。青春期儿童。精神病学,1995,34,7:897-901。
OBJECTIVETo test the hypothesis that methylphenidate reduces thresholds for reward in children with attention-deficit hyperactivity disorder (ADHD).METHODA double-blind crossover design was used in which 16 ADHD boys, aged 8 to 13 years, received methylphenidate on one testing occasion and placebo on another. On each occasion, subjects performed a task that required progressively greater numbers of button presses to earn a fixed monetary payoff.RESULTSThe “breaking point” above which the hyperactive child was unwilling to continue with the task was significantly higher during drug than placebo trials.CONCLUSIONSThe results support an assumption that underlies the reward system dysfunction hypothesis of ADHD, and they suggest that reward mechanisms may underlie the therapeutic effects of stimulants observed across a wide range of tasks and settings. J. Am. Acad. Child Adolesc. Psychiatry, 1995, 34, 7:897–901.
多动儿童中的哌醋甲酯:剂量对冲动行为的影响差异。
DOI: --
发表时间: 1979
期刊: Pediatrics
影响因子: 8
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DOI: --
发表时间: 1988
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影响因子: --
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