Curcumin molecular targets in obesity and obesity-related cancers.
Curcumin molecular targets in obesity and obesity-related cancers.
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DOI：
10.2217/fon.11.145
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发表时间：
2012-02
期刊：
影响因子：
3.3
通讯作者：
A. Shehzad;Salma Khan;Young Sup Lee
中科院分区：
文献类型：
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作者：
A. Shehzad;Salma Khan;Young Sup Lee
肥胖的特征是BMI增加，这与几种常见癌症的风险增加有关，包括结肠直肠癌、乳腺癌、子宫内膜癌、肾癌、食道癌、胆囊癌、黑色素瘤、多发性骨髓瘤、白血病、淋巴瘤和前列腺癌。肥胖相关癌症的风险增加可能是由胰岛素抵抗、脂肪因子、肥胖相关炎性细胞因子、性激素、转录因子和氧化应激介导的，它们破坏了细胞增殖和凋亡之间的平衡。黄色化合物姜黄素（二阿魏酰甲烷）已知具有多方面的药理作用。将肥胖与癌症风险联系起来的分子机制，以及姜黄素如何介导抗癌和肥胖活动，尚未公布。姜黄素调节多个分子靶点，逆转胰岛素抵抗以及与肥胖相关的癌症相关的其他症状。在这项研究中，我们发现有足够的证据支持姜黄素介导多种分子途径的建议，并被认为在治疗和预防肥胖相关癌症方面具有治疗价值。
Obesity is characterized as an increased BMI, which is associated with the increased risk of several common cancers, including colorectal, breast, endometrial, renal, esophageal, gallbladder, melanoma, multiple myeloma, leukemia, lymphoma and prostate cancer. The increased risk of obesity-related cancers could be mediated by insulin resistance, adipokines, obesity-related inflammatory cytokines, sex hormones, transcription factors and oxidative stress, which disrupt the balance between cell proliferation and apoptosis. The yellowish compound, curcumin (diferuloylmethane), is known to possess multifaceted pharmacological effects. The molecular mechanisms linking obesity to cancer risk, and how curcumin mediates anticancer and obesity activities, have not yet been publicized. Curcumin modulates multiple molecular targets and reverses insulin resistance as well as other symptoms that are associated with obesity-related cancers. In this study, we show that ample evidence exists to support recommendations that curcumin mediates multiple molecular pathways, and is considered to be of therapeutic value in the treatment and prevention of obesity-related cancers.