Tissue distribution, bioaccumulation characteristics and health risk of antibiotics in cultured fish from a typical aquaculture area
Tissue distribution, bioaccumulation characteristics and health risk of antibiotics in cultured fish from a typical aquaculture area
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DOI：
10.1016/j.jhazmat.2017.09.017
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发表时间：
2018-02-05
影响因子：
13.6
通讯作者：
Ying, Guang-Guo
中科院分区：
文献类型：
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作者：
Chen, Hui;Liu, Shan;Ying, Guang-Guo
环境中残留的抗生素对生态系统和人类健康的负面影响是令人担忧的。然而，关于抗生素在水产养殖场中的生物积累的信息很少。本研究系统地研究了21种抗生素在典型养殖区养鱼的血浆、胆汁、肝脏和肌肉中的生物蓄积潜力。结果表明：抗生素在养殖鱼中的分布主要受种类和特定物质的影响。鱼血浆、胆汁、肝脏和肌肉组织中抗生素的对数生物累积因子(Log BAFS)平均值分别为0.43~3.70、0.36~4.75、0.31~4.48和0.23~4.33。对于草鱼，环丙沙星和恩诺沙星均表现出较高的从血浆到肌肉和肝脏的转运能力。血浆和其他三种组织中不同抗生素浓度的相关性表明，环丙沙星和恩诺沙星在鱼组织中的浓度可以通过它们在血浆中的浓度来预测。根据计算的危害商数，通过鱼类消费对抗生素暴露的人类健康风险评估表明，这些养殖鱼类的消费对人类健康的风险较低。(C)2017爱思唯尔B.V.保留所有权利。
The negative impacts of residual antibiotics in the environment on ecosystem and human health are big concerns. However, little information is available on the antibiotic bioaccumulation in aquaculture farms. In this study, the bioaccumulative potentials of 21 antibiotics in the plasma, bile, liver and muscle of cultured fish from a typical aquaculture area were systematically investigated.Results: indicated that antibiotic distribution in the cultured fish was mainly influenced by species and specific substances. The mean values of log bioaccumulation factors (Log BAFs) for the detected antibiotics were in the range of 0.43-3.70, 0.36-4.75, 0.31-4.48, and 0.23-4.33 in the fish plasma, bile, liver and muscle tissues, respectively. For grass carp, both ciprofloxacin and enrofloxacin showed high transportability from the plasma to the muscle and liver. The correlations of various antibiotic concentrations between the plasma and the other three tissues indicated that the concentrations of ciprofloxacin and enrofloxacin in the fish tissues could be predicted by their concentrations in the plasma. Based on the calculated hazard quotients, human health risk evaluation of antibiotic exposure by fish consumption indicated that the consumption of these cultured fish posed low risks to human health. (C) 2017 Elsevier B.V. All rights reserved.