Retinotopic and topographic analyses with gaze restriction for steady-state visual evoked potentials
Retinotopic and topographic analyses with gaze restriction for steady-state visual evoked potentials
复制标题
稳态视觉诱发电位的凝视限制视网膜专题和地形分析
DOI：
10.1038/s41598-019-41158-5
复制
发表时间：
2019
影响因子：
4.6
通讯作者：
Hu Dewen
中科院分区：
文献类型：
--
作者：
Zhang Nannan;Liu Yadong;Yin Erwei;Deng Baosong;Cao Lu;Jiang Jun;Zhou Zongtan;Hu Dewen
虽然稳态视觉诱发电位（SSVEPs）的机制已经得到了很好的研究，但没有一个是在严格的实验条件下实现的。我们的目标是创造一个理想的观察者条件，利用SSVEP的功能。我们在这里提出了一个脑电图（EEG）眼动跟踪实验范式，提供生物反馈的凝视限制在视觉刺激。具体而言，我们设计了一个脑电眼动跟踪同步数据记录系统，成功的试验选择。在11.5°视野内连续呈现46次周期性闪烁以诱发SSVEP反应，并提供基于眼动仪的在线生物反馈来限制凝视。对8名受试者，绘制并分析了视野中的SSVEP反应和全脑EEG地形图。实验结果表明，提高SSVEP的最佳视觉闪烁安排应包括4-6°空间距离内的圆形刺激和注视点下方增加的刺激面积。这些发现为确定神经工程研究的刺激参数提供了基础，例如基于SSVEP的脑机接口（BCI）设计。所提出的实验范式也可以为未来的SSVEP相关研究提供一个精确的框架。
Although the mechanisms of steady-state visual evoked potentials (SSVEPs) have been well studied, none of them have been implemented with strictly experimental conditions. Our objective was to create an ideal observer condition to exploit the features of SSVEPs. We present here an electroencephalographic (EEG) eye tracking experimental paradigm that provides biofeedback for gaze restriction during the visual stimulation. Specifically, we designed an EEG eye tracking synchronous data recording system for successful trial selection. Forty-six periodic flickers within a visual field of 11.5° were successively presented to evoke SSVEP responses, and online biofeedback based on an eye tracker was provided for gaze restriction. For eight participants, SSVEP responses in the visual field and topographic maps from full-brain EEG were plotted and analyzed. The experimental results indicated that the optimal visual flicking arrangement to boost SSVEPs should include the features of circular stimuli within a 4–6° spatial distance and increased stimulus area below the fixation point. These findings provide a basis for determining stimulus parameters for neural engineering studies, e.g. SSVEP-based brain-computer interface (BCI) designs. The proposed experimental paradigm could also provide a precise framework for future SSVEP-related studies.