Arterial stiffness and cardiovascular risk factors in a population-based study
Arterial stiffness and cardiovascular risk factors in a population-based study
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DOI：
10.1097/00004872-200103000-00005
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发表时间：
2001-03-01
影响因子：
4.9
通讯作者：
Ferrières, J
中科院分区：
文献类型：
--
作者：
Amar, J;Ruidavets, JB;Ferrières, J
目的确定脉搏波速度（PWV）、动脉扩张性估计值和心血管危险因素之间的关系。设计这项基于人群的横断面研究于1995年至1997年进行，以调查这些关系。人口和方法大约993名受试者，年龄35-64岁（52.7%为男性），居住在法国西南部，从选民名册中随机挑选，并参加了一项横断面研究。体检由受过专门训练的医务人员进行。采用半自动装置测量颈动脉-股动脉PWV（Complior，Garges les Gonesse，France），首先在未用降血脂、抗糖尿病和抗高血压药物治疗的受试者中，然后在治疗的受试者中，评估PWV与风险因素之间的关系。收缩压（SBP）和心率（P< 0.001）是与PWV显著相关的变量PWV与SEP（P <0.001）、心率（P <0.001）、载脂蛋白B（P< 0.05）及心血管危险因素治疗次数（P< 0.05）呈正相关。结论在高危人群中，危险因素的累积影响，即使治疗，也是动脉硬化的独立决定因素。这些结果表明，PWV可以作为一个相关的工具来评估心血管危险因素对高风险患者主动脉僵硬度的影响。J Hypertens 19：381-387（C）2001 Lippincott威廉姆斯和威尔金斯。
Objective To determine the relationships between pulse wave velocity (PWV), an estimate of arterial distensibility and cardiovascular risk factors.Design This cross-sectional population-based study was carried out from 1995 to 1997 to investigate these relationships.Population and methods Some 993 subjects, aged 35-64 years (52.7% men), living in the south-west of France, were randomly selected from electoral rolls and participated in a cross-sectional study. Medical examinations were performed by specially trained medical staff. Carotid-femoral PWV was measured using a semiautomatic device (Complior, Garges les Gonesse, France), The relationships between PWV and risk factors were assessed, first in subjects not treated with hypolipidaemic, antidiabetic and antihypertensive drugs and then in treated subjects, In subjects not treated for cardiovascular risk factors, age, gender, systolic blood pressure (SBP) and heart rate (P< 0.001) were the variables significantly associated with PWV, In treated patients, age (P< 0.01), SEP (P< 0.001), heart rate (P< 0.001), apolipoprotein B (P< 0.05) and the number of treated cardiovascular risk factors (:P< 0.05) were positively correlated with PWV,Conclusion This study shows that, in a sample of subjects at high risk, the cumulative influence of risk factors, even treated, is an independent determinant of arterial stiffness. These results suggest that PWV may be used as a relevant tool to assess the influence of cardiovascular risk factors on aortic stiffness in high-risk patients. J Hypertens 19:381-387 (C) 2001 Lippincott Williams & Wilkins.