Body mass index in long-term adult survivors of childhood cancer - A report of the childhood cancer survivor study
Body mass index in long-term adult survivors of childhood cancer - A report of the childhood cancer survivor study
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DOI：
10.1002/cncr.20960
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发表时间：
2005-04-15
期刊：
影响因子：
6.2
通讯作者：
Oeffinger, KC
中科院分区：
文献类型：
--
作者：
Meacham, LR;Gurney, JG;Oeffinger, KC
背景资料。本研究的目的是确定常见儿童恶性肿瘤幸存者的身体质量指数(BMI)的分布，并确定与BMI异常相关的因素。方法儿童癌症幸存者研究(CCSS)是一项多中心队列研究，研究对象为1970年至1986年间确诊的5年儿童癌症幸存者。自报的身高和体重被用来计算7195名成年幸存者的BMI，与1995年全国健康访谈调查中基于人口、特定年龄和特定性别的标准进行了比较。体重不足定义为BMI=18.5 kg/m(2)，肥胖定义为BMI=30 kg/m(2)。结果：白血病幸存者更容易肥胖(女性：优势比[OR]=1.5；95%可信区间[CI]1.2-1.8；男性：OR=1.2；95%CI，1.0-1.5)。更有可能体重不足的幸存者包括霍奇金病(OR=1.7；95%CI，1.3-2.3和OR 3.5；95%CI，2.3-5.3)和Wilms肿瘤患者(OR=1.8；95%CI，1.2-2.8和OR=5.5；95%CI，3.1-9.7)，未截肢的骨癌女性幸存者(OR=1.9；95%CI，1.2-2.9)，以及白血病男性幸存者(OR=2.4；脑肿瘤(OR=2.7；95%CI，1.6~4.4)、非霍奇金淋巴瘤(OR=3.1；95%CI，1.9~5.2)、神经母细胞瘤(OR=4.9；95%CI，2.48~10.0)、软组织肉瘤(OR 3.5；95%CI，2.0~6.0)。在女性中，接受全身照射、烷化剂和蒽环类药物治疗，在男性中，接受腹部放射治疗，治疗时年龄较小，以及使用蒽环类药物和烷化剂治疗与体重过轻有关。体重不足的幸存者更有可能报告不良的健康状况和重大的医疗状况。结论：相当大比例的儿童癌症幸存者成年后体重过轻，这对幸存者总体健康的影响需要进一步解决。(C)2005年美国癌症协会。
BACKGROUND. The goals of the current study were to determine the distribution of body mass index (BMI) of survivors of common pediatric malignancies and to identify factors associated with abnormal BMI.METHODS. The Childhood Cancer Survivor Study (CCSS) is a multicenter cohort study of >= 5-year survivors of pediatric cancer diagnosed between 1970 and 1986. Self-reported heights and weights were used to calculate BMI for 7195 adult survivors, compared with population-based, age-specific, and gender-specific norms from the 1995 National Health Interview Survey. Underweight was defined as a BMI < 18.5 kg/m(2) and obese as BMI >= 30 kg/m(2).RESULTS. Survivors of leukemia were more likely to be obese (females: odds ratio [OR] = 1.5; 95% confidence interval [CI], 1.2-1.8; males: OR = 1.2; 95% CI, 1.0-1.5). Survivors more likely to be underweight included female and male survivors of Hodgkin disease (OR = 1.7; 95% CI, 1.3-2.3 and OR 3.5; 95% CI, 2.3-5.3) and Wilms tumor (OR = 1.8; 95% CI, 1.2-2.8 and OR = 5.5; 95% CI, 3.1-9.7), female survivors of bone carcinoma without amputation (OR = 1.9; 95% CI, 1.2-2.9), and male survivors of leukemia (OR = 2.4; 95% CI, 1.6-3.6), brain tumors (OR = 2.7; 95% CI, 1.6-4.4), non-Hodgkin lymphoma (OR = 3.1; 95% CI, 1.9-5.2), neuroblastoma (OR = 4.9; 95% CI, 2.48-10.0), and soft tissue sarcoma (OR 3.5; 95% CI, 2.0-6.0). In females, treatment with total body irradiation, alkylating agents, and anthracyclines and in males, treatment with abdominal radiation, younger age at treatment, and treatment with anthracyclines and alkylating agents were associated with being underweight. Underweight survivors were more likely to report adverse health and major medical conditions.CONCLUSIONS. A significant proportion of childhood survivors of cancer are underweight as adults and the impact of this on the general health of survivors will need to be addressed further. (c) 2005 American Cancer Society.