Sleep Timing, Stability, and BP in the Sueno Ancillary Study of the Hispanic Community Health Study/Study of Latinos
Sleep Timing, Stability, and BP in the Sueno Ancillary Study of the Hispanic Community Health Study/Study of Latinos
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DOI：
10.1016/j.chest.2018.09.018
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发表时间：
2019-01-01
期刊：
影响因子：
9.6
通讯作者：
Zee, Phyllis C.
中科院分区：
文献类型：
--
作者：
Abbott, Sabra M.;Weng, Jia;Zee, Phyllis C.
背景：睡眠-觉醒周期的时间和稳定性是心脏代谢疾病的潜在可改变的危险因素。本研究的目的是评估睡眠-觉醒时间和稳定性的客观指标与心脏代谢疾病风险之间的关系。方法：在这项多中心、横断面、基于人群的研究中，从西班牙裔社区健康研究/拉丁裔研究（2010-2013年）的Suefio辅助研究中招募的2,156名年龄在18至64岁的成年人中获得体动记录数据。这些数据与心脏代谢疾病风险指标相关，包括收缩压和舒张压、胰岛素抵抗的稳态评估、糖基化血红蛋白、BMI以及高血压和糖尿病状态。结果：每日稳定性每下降10%，高血压患病率绝对增加3.0%（95% CI，0.6-5.3; P < .05），收缩压增加0.78 mm Hg（95% CI，0.12-1.45; P < .05），舒张压增加0.80 mm Hg（95% CI，0.28-1.32; P < .05）。此外，睡眠中点延迟1小时与收缩压增加0.73 mm Hg（95% CI，0.30-1.16; P <0.01）和舒张压增加0.53 mm Hg（95% CI，0.17-0.90; P <0.01）相关。在调整轮班工作状态后，这些关联并不显著。没有关联被发现interdaily稳定性或睡眠时间和糖尿病，BMI，或insulin resistance.CONCLUSIONS：这些结果表明，除了睡眠时间，时间和规律的睡眠觉醒时间表与高血压患病率和血压。
BACKGROUND: Timing and stability of the sleep-wake cycle are potential modifiable risk factors for cardiometabolic disease. The aim of this study was to evaluate the relationship between objective measures of sleep-wake timing and stability with cardiometabolic disease risk.METHODS: In this multicenter, cross-sectional, population-based study, actigraphy data were obtained from the 2,156 adults, aged 18 to 64 years, recruited from the Suefio ancillary study of the Hispanic Community Health Study/Study of Latinos (2010-2013). These data were correlated with measures of cardiometabolic disease risk, including systolic and diastolic BPs, homeostatic assessment of insulin resistance, glycosylated hemoglobin, BMI, and hypertension and diabetes status.RESULTS: Each 10% decrease in interdaily stability was associated with a 3.0% absolute increase in the prevalence of hypertension (95% CI, 0.6-5.3; P < .05), an increase in systolic BP by 0.78 mm Hg (95% CI, 0.12-1.45; P < .05) and an increase in diastolic BP by 0.80 mm Hg (95% CI, 0.28-1.32; P < .05). In addition, delaying the midpoint of sleep by 1 h was associated with an increase in systolic BP by 0.73 mm Hg (95% CI, 0.30-1.16; P < .01) and diastolic BP by 0.53 mm Hg (95% CI, 0.17-0.90; P < .01). These associations were not significant after adjusting for shift work status. No association was found between interdaily stability or sleep timing and diabetes, BMI, or insulin resistance.CONCLUSIONS: These results suggest that beyond sleep duration, the timing and regularity of sleep-wake schedules are related to hypertension prevalence and BP.