Functional connectivity of the visual cortex differentiates anxiety comorbidity from episodic migraineurs without aura.
Functional connectivity of the visual cortex differentiates anxiety comorbidity from episodic migraineurs without aura.
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视觉皮层的功能连通性区分焦虑性合并症与无先兆的发作性偏头痛
DOI：
10.1186/s10194-021-01259-x
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发表时间：
2021-05-21
期刊：
影响因子：
--
通讯作者：
Zhang H
中科院分区：
文献类型：
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作者：
Wei HL;Li J;Guo X;Zhou GP;Wang JJ;Chen YC;Yu YS;Yin X;Li J;Zhang H
偏头痛是一种常见的神经系统疾病，常伴有精神疾病。然而，偏头痛患者的脑功能异常和精神共病之间的关系在很大程度上仍然不清楚。因此，本研究旨在探讨无先兆偏头痛（MwoA）患者的静息状态功能障碍与精神共病之间的相关性。获得静息状态功能磁共振图像。此外，低频波动（ALFF）和区域均匀性（ReHo）值的振幅。此后，选择伴有和不伴有焦虑的MwoA患者（MwoA-A和MwoA-OA）的区域异常作为种子进行功能连接（FC）分析。MwoA-A和MwoA-OA患者右侧舌回（LG）的ALFF和ReHo值与健康对照组（HC）相比异常。右侧LG与同侧上级额回（SFG）和扣带回中部（MCC）的FC也异常。此外，与MwoA-OA患者相比，MwoA-A患者在左侧后顶内沟（pIPS）中显示出更高的ReHo值，并且与同侧pIPS和初级视觉皮层一起显示出右侧LG的异常FC。此外，MwoA-OA患者的右侧后扣带回/楔前叶（PCC/PCUN）、左侧额中回（MFG）和左侧颞下回（ITG）的FC相对于HC增加。MwoA-A患者右侧LG的ALFF值与焦虑评分呈正相关。在MwoA-OA患者中，与PCC/PCUN、MFG和ITG相关的异常LG FC与头痛频率呈负相关。这项研究确定了异常视觉FC沿着其他核心网络区分焦虑合并症从MwoA。因此，这可能会增强对精神病合并症的神经心理学基础的理解，并提供新的见解，可能有助于发现新的标志甚至治疗靶点。
Migraine is a common neurological disease that is often accompanied by psychiatric comorbidities. However, the relationship between abnormal brain function and psychiatric comorbidities in migraine patients remains largely unclear. Therefore, the present study sought to explore the correlations between the resting-state functional deficits and psychiatric comorbidities in migraine without aura (MwoA) patients. Resting-state functional magnetic resonance images were obtained. In addition, the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) values were obtained. Thereafter regional abnormalities in MwoA patients with and without anxiety (MwoA-A and MwoA-OA) were chosen as seeds to conduct functional connectivity (FC) analysis. Compared to the healthy controls (HCs), the MwoA-A and MwoA-OA patients had abnormal ALFF and ReHo values in the right lingual gyrus (LG). They also had abnormal FC of the right LG with the ipsilateral superior frontal gyrus (SFG) and middle cingulate cortex (MCC). Additionally, the MwoA-A patients showed higher ReHo values in the left posterior intraparietal sulcus (pIPS) and abnormal FC of the right LG with ipsilateral pIPS and primary visual cortex, compared to the MwoA-OA patients. Moreover, the MwoA-OA patients showed an increase in the FC with the right posterior cingulate cortex/precuneus (PCC/PCUN), left middle frontal gyrus (MFG) and left inferior temporal gyrus (ITG) relative to the HCs. Furthermore, the ALFF values of the right LG positively were correlated with anxiety scores in MwoA-A patients. The abnormal LG-related FCs with the PCC/PCUN, MFG and ITG were negatively associated with the frequency of headaches in MwoA-OA patients. This study identified abnormal visual FC along with other core networks differentiating anxiety comorbidity from MwoA. This may therefore enhance the understanding of the neuropsychological basis of psychiatric comorbidities and provide novel insights that may help in the discovery of new marks or even treatment targets.