Association of polymorphisms in 5-HTT (SLC6A4) and MAOA genes with measures of obesity in young adults of Portuguese origin
Association of polymorphisms in 5-HTT (SLC6A4) and MAOA genes with measures of obesity in young adults of Portuguese origin
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DOI：
10.3109/13813455.2015.1111390
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发表时间：
2016-01-01
影响因子：
3
通讯作者：
Manco, Licinio
中科院分区：
文献类型：
--
作者：
Dias, Helena;Muc, Magdalena;Manco, Licinio
目的：探讨SLC 6A 4和MAOA基因多态性与超重（包括肥胖）的关系。材料和方法：对葡萄牙血统的年轻人（n=535）进行SLC 6A 4多态性5-HTTLPR和STin 2和MAOA VNTR基因分型。测量BMI和体脂百分比，并采用问卷调查法评估个体的体育锻炼习惯。结果如下：在整个研究样本中，基于单倍型的分析揭示了个体5-HTTLPR/Stin 2单倍型L10与超重/肥胖的显著关联（p=0.04）。在男性中，MAOA 3R基因型名义上与体脂相关（p=0.04）。在不活动的个体中，发现超重/肥胖与5-HTTLPR L-等位基因显著相关（p=0.01），名义上与STin 2 10-等位基因相关（p=0.03）。对所有单倍型效应进行检验也发现了显著关联（（2）=8.7; p=0.03）。结论：SLC 6A 4和MAOA基因与肥胖相关。我们的研究结果表明，缺乏体力活动加重了SLC 6A 4多态性对肥胖风险的影响。
Objectives: To investigate the association of polymorphisms in SLC6A4 and MAOA genes with overweight (including obesity). Material and methods: Young adults (n=535) of Portuguese origin were genotyped for the SLC6A4 polymorphisms 5-HTTLPR and STin2 and a MAOA VNTR. BMI and body fat percentage were measured and a questionnaire was used to assess individual's sport practicing habits. Results: In whole study sample, haplotype-based analysis revealed significant association with overweight/obesity for the individual 5-HTTLPR/Stin2 haplotype L10 (p=0.04). In men, the MAOA 3R genotype was nominally associated with body fat (p=0.04). In inactive individuals, overweight/obesity was found significantly associated with 5-HTTLPR L-allele (p=0.01) and nominally associated with STin2 10-allele (p=0.03). A significant association was also found testing for all haplotype effects ((2)=8.7; p=0.03). Conclusions: We found some evidences for the association of SLC6A4 and MAOA genes with measures of obesity. Our results suggest physical inactivity accentuates the influence of SLC6A4 polymorphisms on obesity risk.