THE EFFECT OF INTERSCAPULAR BROWN ADIPOSE-TISSUE REMOVAL ON BODY-WEIGHT AND COLD RESPONSE IN THE MOUSE
THE EFFECT OF INTERSCAPULAR BROWN ADIPOSE-TISSUE REMOVAL ON BODY-WEIGHT AND COLD RESPONSE IN THE MOUSE
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DOI：
10.1079/bjn19820077
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发表时间：
1982-01-01
影响因子：
3.6
通讯作者：
CARNIE, JA
中科院分区：
文献类型：
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作者：
CONNOLLY, E;MORRISEY, RD;CARNIE, JA
与麻醉对照组相比，肩胛间棕色脂肪组织（IBAT）的去除导致正常瘦小鼠体重增加。在实验期间，在两组小鼠之间未检测到摄食量的显著差异。用氯仿：甲醇对整个尸体进行脂肪提取，结果显示，未使用IBAT的动物脂肪含量在统计学上显著增加。当暴露于冷应激情况（4 ℃）时，在手术动物中没有明显的失败来维持核心温度。24小时）。手术组和对照组小鼠颈背部棕色脂肪组织的湿重、蛋白质含量和细胞色素氧化酶含量均无差异。这表明手术小鼠中其他棕色脂肪组织部位响应于IBAT的去除而缺乏增殖。棕色脂肪组织可能与小鼠的饮食产热有关。
The removal of the interscapular brown adipose tissue (IBAT) led to an increase in body weight of normal, lean mice as compared to anesthetized controls. No significant difference in food consumption could be detected between the 2 groups of mice over the period of the experiment. Fat extraction of the whole carcasses with chloroform:methanol showed a statistically significant increase in fat content in the animals without IBAT. There was no apparent failure in the operated animals to sustain core temperature when exposed to a cold stress situation (4.degree. C for 24 h). There was no difference in the wet weight, protein content or cytochrome oxidase content of the dorso-cervical brown adipose tissue between operated and control mice. This is indicative of a lack of proliferation of other brown adipose tissue sites in the operated mice in response to the removal of the IBAT. Brown adipose tissue may be implicated in dietary thermogenesis in the mouse.