Inter- and Intra-individual Variations in Foveal Outer Nuclear Layer Thickness and Their Associations with Clinical Characteristics in a Healthy Chinese Population
Inter- and Intra-individual Variations in Foveal Outer Nuclear Layer Thickness and Their Associations with Clinical Characteristics in a Healthy Chinese Population
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DOI：
10.1155/2020/7967393
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发表时间：
2020-05
影响因子：
1.9
通讯作者：
Jia Yu;Lei Li;Chunhui Jiang;Q. Chang;Qi Zhao
中科院分区：
文献类型：
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作者：
Jia Yu;Lei Li;Chunhui Jiang;Q. Chang;Qi Zhao
目的探讨健康中国人双眼黄斑中心凹外核层（ONL）厚度的差异及其与临床特征的关系。材料与方法正常受试者。广义线性模型用于评估中心凹ONL厚度与性别、年龄和等效球镜（SE）的相关性，以及双眼中心凹ONL厚度差异与性别、年龄和双眼SE差异的相关性。结果共纳入304例受试者。右眼中心凹ONL平均厚度为103.19 ± 14.25（范围70-151）μm，左眼为103.90 ± 14.63（范围69-155）μm。右眼和左眼之间的中央凹ONL厚度的平均差异为−0.71 ± 4.36（范围为−13至+12）μm。与女性相比，男性右眼和左眼的中央凹ONL厚度值略大（均P 0.05）。性别、年龄、双眼SE差异与双眼黄斑中心凹ONL厚度差异无相关性（均P > 0.05）。结论正常中国人黄斑中心凹ONL厚度差异较大，但双眼间差异不大。这两个参数不能通过性别、年龄、SE或双眼SE差异进行调整。因此，在仅涉及一只眼睛的那些疾病中，受影响的眼睛和正常的对侧眼睛之间的中央凹ONL厚度的差异或比率可以反映疾病的实际程度，而不是仅受影响的眼睛中的中央凹ONL厚度。
Purpose To evaluate foveal outer nuclear layer (ONL) thickness and the difference thereof between bilateral eyes and their possible associations with clinical characteristics in a healthy Chinese population. Materials and Methods Normal subjects were enrolled. Generalized linear models were used to assess the associations of foveal ONL thickness with sex, age, and spherical equivalents (SEs) and the associations of the difference in foveal ONL thickness between bilateral eyes with sex, age, and difference in SEs between bilateral eyes. Results Totally, 304 subjects were included. The average foveal ONL thickness was 103.19 ± 14.25 (range 70–151) μm in the right eye and 103.90 ± 14.63 (range 69–155) μm in the left eye. The mean difference in foveal ONL thickness between right and left eyes was −0.71 ± 4.36 (range −13 to +12) μm. Men had slightly greater foveal ONL thickness values in both right and left eyes compared with women (both P 0.05). Sex, age, and difference in SEs between bilateral eyes were not associated with the difference in foveal ONL thickness between bilateral eyes (all P > 0.05). Conclusions Foveal ONL thickness showed wide variation in a normal Chinese population but little difference between bilateral eyes. Both these parameters could not be adjusted by sex, age, SEs, or the SEs difference between bilateral eyes. Thus, in those diseases involving only one eye, the difference or ratio of foveal ONL thickness between the affected eye and normal fellow eye may reflect the actual degree of the disease, rather than the foveal ONL thickness in the affected eye alone.