Frequency-Specific Neural Signatures of Spontaneous Low-Frequency Resting State Fluctuations in Psychosis: Evidence From Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Consortium
Frequency-Specific Neural Signatures of Spontaneous Low-Frequency Resting State Fluctuations in Psychosis: Evidence From Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Consortium
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DOI：
10.1093/schbul/sbv064
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发表时间：
2015-11-01
影响因子：
6.6
通讯作者：
Pearlson, Godfrey D.
中科院分区：
文献类型：
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作者：
Meda, Shashwath A.;Wang, Zheng;Pearlson, Godfrey D.
我们使用来自大型 BSNIP 家族研究的静息功能磁共振成像数据，量化了精神分裂症 (SZ)-精神病性双相情感障碍 (PBP) 精神病谱系的低频波动 (ALFF/fALFF) 的频率特异性、绝对幅度和分数幅度。我们评估了 242 名健康对照 (HC)、547 名先证者（180 名 PBP、220 名 SZ 和 147 名精神分裂情感者）。障碍-SAD），以及 410 名其一级亲属（134 名 PBPR、150 名 SZR 和 126 名 SADR）。按照统计参数映射 (SPM8) 中的标准预处理，我们计算了 2 个低频段的绝对功率和分数功率 (ALFF/fALFF)：慢速 5 (0.01-0.027 Hz) 和慢速 4 (0.027-0.073 Hz)。我们评估了传统《精神疾病诊断与统计手册》第四版诊断类别中的体素事后差异。在 ALFF/fALFF 中，与 HC 相比，BP/SAD 显示慢 5 频带中额叶/前脑区域的低激活以及慢 4 频带中后脑区域的低激活。 SZ 在两个带和指数上都表现出楔前叶/楔叶和后扣带皮一致的低激活。 ALFF/fALFF 增加主要出现在先证者的深部皮层下和颞叶结构中，无论是带还是指数。在先证者中，SAD 的空间 ALFF/fALFF 差异比 SZ 更类似于 PBP。在亲属中未检测到这些 ALFF/fALFF 差异。结果表明 ALFF/fALFF 是假定的生物标志物，而不是家族内表型。 fALFF 对区分先证者大脑改变的总体敏感性比 ALFF 更强。 SAD 中观察到的差异模式与 PBP 中观察到的差异模式更为相似。在 2 个频段上注意到了不同的影响，与 SZ 相比，BP/SAD 的影响更为显着，这表明前者的频率敏感生理机制。
We quantified frequency-specific, absolute, and fractional amplitude of low-frequency fluctuations (ALFF/fALFF) across the schizophrenia (SZ)-psychotic bipolar disorder (PBP) psychosis spectrum using resting functional magnetic resonance imaging data from the large BSNIP family study.We assessed 242 healthy controls (HC), 547 probands (180 PBP, 220 SZ, and 147 schizoaffective disorder-SAD), and 410 of their first-degree relatives (134 PBPR, 150SZR, and 126 SADR). Following standard preprocessing in statistical parametric mapping (SPM8), we computed absolute and fractional power (ALFF/fALFF) in 2 low-frequency bands: slow-5 (0.01-0.027 Hz) and slow-4 (0.027-0.073 Hz). We evaluated voxelwise post hoc differences across traditional Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnostic categories.Across ALFF/fALFF, in contrast to HC, BP/SAD showed hypoactivation in frontal/anterior brain regions in the slow-5 band and hypoactivation in posterior brain regions in the slow-4 band. SZ showed consistent hypoactivation in precuneus/cuneus and posterior cingulate across both bands and indices. Increased ALFF/fALFF was noted predominantly in deep subcortical and temporal structures across probands in both bands and indices. Across probands, spatial ALFF/fALFF differences in SAD resembled PBP more than SZ. None of these ALFF/fALFF differences were detected in relatives.Results suggest ALFF/fALFF is a putative biomarker rather than a familial endophenotype. Overall sensitivity to discriminate proband brain alteration was stronger for fALFF than ALFF. Patterns of differences noted in SAD were more similar to those observed in PBP. Differential effects were noted across the 2 frequency bands, more prominently for BP/SAD compared with SZ, suggesting frequency-sensitive physiologic mechanisms for the former.