Relationship between arterial stiffness and subclinical aortic atherosclerosis
Relationship between arterial stiffness and subclinical aortic atherosclerosis
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DOI：
10.1161/01.cir.0000136582.33493.cc
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发表时间：
2004-07-27
期刊：
影响因子：
37.8
通讯作者：
Raines, J
中科院分区：
文献类型：
--
作者：
Herrington, DM;Brown, V;Raines, J
背景-动脉顺应性的非侵入性措施可能是有用的检测亚临床atherosclerosis.Methods和Results-Measures小腿和大腿动脉顺应性（MaxV 50）被记录在267例受试者谁也接受了MRI的远端主动脉量化远端主动脉粥样硬化。小腿和大腿MaxV 50的平均值强烈预测主动脉粥样硬化的程度，以及在校正Fracket冠状动脉风险评分（FCRS）或FCRS和C反应蛋白的组合后，主动脉粥样硬化的前四分位数的风险（P < 0.0001）。预测性别特异性主动脉粥样硬化的前四分位数的受试者工作曲线下的面积分别为0.57，0.60和0.75的模型包含FCRS，FCRS和C-反应蛋白，和FCRS，C-反应蛋白，小腿和大腿MaxV 50的平均值。结论下肢动脉顺应性可能会识别广泛的亚临床动脉粥样硬化的主题。进一步研究动脉硬度作为筛选工具的潜在价值，以指导更积极的预防性干预措施的启动是必要的。
Background-Noninvasive measures of arterial compliance may be useful for the detection of subclinical atherosclerosis.Methods and Results-Measures of calf and thigh arterial compliance (MaxV50) were recorded in 267 subjects who also underwent MRI of the distal aorta to quantify distal aorta atherosclerosis. The average of calf and thigh MaxV50 was strongly predictive of extent of aortic atherosclerosis and risk of being in the top quartile of aortic atherosclerosis after adjustment for the Framingham Coronary Risk Score ( FCRS) or the combination of the FCRS and C-reactive protein (P < 0.0001). The areas under the receiver operating curves predicting the top quartile of gender-specific aortic atherosclerosis were 0.57, 0.60, and 0.75 for models containing the FCRS, the FCRS and C-reactive protein, and the FCRS, C-reactive protein, and the average of calf and thigh MaxV50.Conclusions-Lower-extremity arterial compliance may identify subjects with extensive subclinical atherosclerosis. Further studies examining the potential value of arterial stiffness as a screening tool to guide initiation of more aggressive preventive interventions are warranted.