Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer.
Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer.
复制标题
针对癌症干细胞的溶瘤病毒：治疗胃肠道癌症的一种有前途的方法
DOI：
10.3748/wjg.v22.i35.7999
复制
发表时间：
2016-09-21
影响因子：
4.3
通讯作者：
Wang YG
中科院分区：
文献类型：
--
作者：
Huang F;Wang BR;Wu YQ;Wang FC;Zhang J;Wang YG
Gastrointestinal cancer has been one of the five most commonly diagnosed and leading causes of cancer mortality over the past few decades. Great progress in traditional therapies has been made, which prolonged survival in patients with early cancer, yet tumor relapse and drug resistance still occurred, which is explained by the cancer stem cell (CSC) theory. Oncolytic virotherapy has attracted increasing interest in cancer because of its ability to infect and lyse CSCs. This paper reviews the basic knowledge, CSC markers and therapeutics of gastrointestinal cancer (liver, gastric, colon and pancreatic cancer), as well as research advances and possible molecular mechanisms of various oncolytic viruses against gastrointestinal CSCs. This paper also summarizes the existing obstacles to oncolytic virotherapy and proposes several alternative suggestions to overcome the therapeutic limitations.
登录
查看更多内容
影响因子：
--
作者：
Achard C;Boisgerault N;Delaunay T;Roulois D;Nedellec S;Royer PJ;Pain M;Combredet C;Mesel-Lemoine M;Cellerin L;Magnan A;Tangy F;Grégoire M;Fonteneau JF
通讯作者：
Fonteneau JF
影响因子：
168.9
作者：
Cunningham, David;Atkin, Wendy;Starling, Naureen
通讯作者：
Starling, Naureen
影响因子：
5.7
作者：
Gujar, Shashi A.;Marcato, Paola;Lee, Patrick W. K.
通讯作者：
Lee, Patrick W. K.
影响因子：
11.2
作者：
Diaconu, Iulia;Cerullo, Vincenzo;Hemminki, Akseli
通讯作者：
Hemminki, Akseli
影响因子：
11.2
作者：
Bach, Patricia;Abel, Tobias;Buchholz, Christian J.
通讯作者：
Buchholz, Christian J.