Endurance Exercise Reduces Hepatic Fat Content and Serum Fibroblast Growth Factor 21 Levels in Elderly Men
Endurance Exercise Reduces Hepatic Fat Content and Serum Fibroblast Growth Factor 21 Levels in Elderly Men
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DOI：
10.1210/jc.2015-3308
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发表时间：
2016-01-01
影响因子：
5.8
通讯作者：
Higuchi, Mitsuru
中科院分区：
文献类型：
--
作者：
Taniguchi, Hirokazu;Tanisawa, Kumpei;Higuchi, Mitsuru
背景：与年龄相关的肝脏脂肪积累增加了心脏代谢疾病的风险，脂肪肝引起的成纤维细胞生长因子（FGF） 21抵抗状态是这些疾病的发病机制的基础。目的：先前的研究表明，较高的心肺健康水平与较低的肝脏脂肪含量和血清FGF21水平相关；然而，耐力运动对肝脏脂肪含量和血清FGF21浓度的影响尚未见研究。因此，我们旨在阐明耐力运动是否会降低肝脏脂肪含量和血清FGF21水平。设计：这是一项随机交叉试验。环境：研究环境为制度实践。患者：33名日本老年男性参与了这项研究。干预：干预是一项为期5周的耐力锻炼计划，包括每周3次循环测力仪训练。主要观察指标：质子磁共振波谱法测定肝脏脂肪含量，ELISA法测定血清FGF21水平。结果：5周耐力运动计划降低了肝脏脂肪含量和血清FGF21水平，但体重没有减轻，运动期的变化高于对照组（P = 0.021和P = 0.026）。相关性分析显示，只有肝脏脂肪含量的变化与血清FGF21水平的变化呈显著正相关（r = 0.366, P = 0.006）。结论：为期5周的耐力运动可降低老年男性肝脏脂肪含量和血清FGF21水平，而体重未减轻，运动诱导的肝脏脂肪减少介导了血清FGF21水平的降低。这些发现表明，耐力运动调节肝脏脂肪含量和FGF21抵抗，无论肥胖状况如何。
Context: Age-related hepatic fat accumulation increases the risk of cardiometabolic diseases, and the fibroblast growth factor (FGF) 21-resistant state caused by fatty liver underlies the pathogenesis of these diseases.Objective: Previous studies suggested that a higher level of cardiorespiratory fitness was associated with both lower hepatic fat content and serum FGF21 levels; however, the effect of endurance exercise on hepatic fat content and serum FGF21 concentration has not been studied. Therefore, we aimed to elucidate whether endurance exercise reduced hepatic fat content and serum FGF21 levels.Design: This is a randomized crossover trial.Setting: The study setting was an institutional practice.Patients: Thirty-three elderly Japanese men participated in the study.Intervention: The intervention was a 5-week endurance exercise program comprising three cycle ergometer sessions per week.Main Outcome Measures: Hepatic fat content was assessed by proton magnetic resonance spectroscopy, and serum FGF21 level was determined by ELISA.Results: A5-week endurance exercise program decreased the hepatic fat content and serum FGF21 levels without weight loss, and the changes were higher in the exercise period than in the control period (P = .021 and P = .026, respectively). Correlation analysis demonstrated that only the change in hepatic fat content was significantly and positively correlated with change in serum FGF21 levels (r = 0.366, P = .006).Conclusions: A 5-week endurance exercise program decreased hepatic fat content and serum FGF21 levels without weight loss in elderly men, and exercise-induced hepatic fat reduction mediated the reduction in serum FGF21 levels. These findings suggest that endurance exercise modulates hepatic fat content and FGF21 resistance, regardless of obesity status.