Rapid-onset type 1 diabetes associated with cytomegalovirus infection and islet autoantibody synthesis
Rapid-onset type 1 diabetes associated with cytomegalovirus infection and islet autoantibody synthesis
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DOI：
10.2169/internalmedicine.46.6395
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发表时间：
2007-01-01
影响因子：
1.2
通讯作者：
Noda, Mitsuhiko
中科院分区：
文献类型：
--
作者：
Osame, Keiichiro;Takahashi, Yoshihiko;Noda, Mitsuhiko
We report the case of a 59-year-old woman who developed rapid-onset type 1 diabetes associated with a marked increase in anti-glutamic acid decarboxylase antibody titer (317.5 U/ml), mild increase in HbA1c level (6.8%), diabetic ketoacidosis, and cytomegalovirus enterocolitis. She was a heterozygote for HLA class II DRB1* 0901-DQA1* 03-DQB1* 0303, and she had HLA class I A24, which may have contributed to the rapid beta cell destruction. Based on the putative molecular mimicry of GAD65 by cytomegalovirus antigen, we hypothesize that the type 1 diabetes in this case was associated with cytomegalovirus infection.
