Pleural Fluid Soluble Interleukin-2 Receptor as a Biomarker for the Diagnosis of Tuberculosis Pleural Effusion: A Systematic Review and Meta-Analysis.
Pleural Fluid Soluble Interleukin-2 Receptor as a Biomarker for the Diagnosis of Tuberculosis Pleural Effusion: A Systematic Review and Meta-Analysis.
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DOI：
10.1155/2022/4348063
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发表时间：
2022
影响因子：
2.2
通讯作者：
Hu ZD
中科院分区：
文献类型：
--
作者：
Yan Z;Wang H;Zheng WQ;Hu ZD
多项研究评估了胸水可溶性白细胞介素 2 受体 (sIL-2R) 对结核性胸腔积液 (TPE) 的诊断准确性，但结果各不相同。因此，我们进行了系统评价和荟萃分析，以评估 sIL-2R 对于 TPE 的准确性。 对 PubMed、Ovid 和 Web of Science 数据库进行了检索，从最初到 2021 年 3 月 23 日，以确定有关 TPE 液体 sIL-2R 诊断准确性的合格研究。将 sIL-2R 对 TPE 的敏感性和特异性与双变量模型进行汇总。我们通过总结受试者工作特征 (sROC) 曲线估计了 PE sIL-2R 的整体诊断准确性。修订后的诊断准确性研究质量评估工具（QUADAS-2）用于评估合格研究的质量。 最终分析共纳入 9 项研究，涉及 270 个 TPE 和 586 个非 TPE。汇总的敏感性和特异性分别为 0.81 (95% CI: 0.76–0.86) 和 0.92 (95% CI: 0.77–0.98)。 sROC 曲线下面积 (AUC) 为 0.82 (95% CI: 0.79–0.86)。没有观察到显着的发表偏倚。 胸水 sIL-2R 是 TPE 的有用诊断标志物。然而，现有生物标志物（例如胸水腺苷脱氨酶、干扰素-γ 和白介素-27）的诊断准确性似乎优于 sIL-2R。因此，使用 sIL-2R 来诊断 TPE 可能不是更好的选择。
Several studies have assessed the diagnostic accuracy of pleural fluid soluble interleukin-2 receptor (sIL-2R) for tuberculous pleural effusion (TPE) but with varied results. Therefore, we conducted this systematic review and meta-analysis to evaluate the accuracy of sIL-2R for TPE. PubMed, Ovid, and Web of Science databases were searched from inception to 23 March 2021 to identify eligible studies concerning the diagnostic accuracy of fluid sIL-2R for TPE. The sensitivity and specificity of sIL-2R for TPE were pooled with a bivariate model. We estimated the global diagnostic accuracy of PE sIL-2R with a summary receiver operating characteristic (sROC) curve. The revised Quality Assessment for Diagnostic Accuracy Studies tool (QUADAS-2) was used to assess the quality of eligible studies. A total of nine studies with 270 TPEs and 586 non-TPEs were included in the final analysis. The pooled sensitivity and specificity were 0.81 (95% CI: 0.76–0.86) and 0.92 (95% CI: 0.77–0.98), respectively. The area under the sROC curve (AUC) was 0.82 (95% CI: 0.79–0.86). No significant publication bias was observed. Pleural fluid sIL-2R is a useful diagnostic marker for TPE. However, the diagnostic accuracies of already available biomarkers such as pleural fluid adenosine deaminase, interferon-γ, and interleukin-27 appear to be superior relative to sIL-2R. Therefore, it might not be preferable to use sIL-2R for diagnosing TPE.