Serum tissue inhibitors of metalloproteinases 1 (TIMP-1) and carotid atherosclerosis and aortic arterial stiffness
Serum tissue inhibitors of metalloproteinases 1 (TIMP-1) and carotid atherosclerosis and aortic arterial stiffness
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DOI：
10.1097/01.hjh.0000191245.68443.24
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发表时间：
2005-12
影响因子：
4.9
通讯作者：
M. Zureik;J. Beaudeux;D. Courbon;A. Benetos;P. Ducimetiere
中科院分区：
文献类型：
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作者：
M. Zureik;J. Beaudeux;D. Courbon;A. Benetos;P. Ducimetiere
研究背景实验研究表明基质金属蛋白酶（matrix metalloproteinases，MMPs）及其抑制剂（tissue inhibitors of metalloproteinases，TIMPs）参与血管重构。在一项基于人群的研究中，我们报告了血清TIMP-1与颈动脉内膜中层厚度、颈动脉斑块和主动脉僵硬度的关系。方法对238例无冠心病的男性进行免费体检，年龄56.5 ± 10.4岁，高血压占57.1%。颈动脉-股动脉脉搏波速度（PWV）用于评估主动脉僵硬度。颈动脉超声检查包括颈总动脉（CCA）内膜-中层厚度（IMT）的测量（在无斑块的部位）和颅外颈动脉粥样硬化斑块的评估。结果TIMP-1值低的受试者中，斑块发生率较低（趋势P = 0.0001）。在校正年龄、体重指数、吸烟习惯、总胆固醇、甘油三酯、C反应蛋白、心率、糖尿病和收缩压的多变量分析中，TIMP-1高值（三分位数3）与低值（三分位数1）受试者颈动脉斑块的比值比为2.89（95%置信区间1.12-7.47，P < 0.01）。单因素分析显示TIMP-1与颈总动脉IMT、PWV呈正相关。然而，一旦在多变量分析中考虑到年龄和收缩压，这种关联就消失了。结论TIMP-1与PWV、CCA-IMT及颈动脉斑块存在一定的相关性。我们的研究结果表明，TIMP-1可能参与斑块形成。
Background The results of experimental studies have suggested that matrix metalloproteinases (MMPs) and their inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), are involved in vascular remodeling. In a population-based study, we report the relationships of serum TIMP-1 with carotid intima–media thickness, carotid plaques and aortic arterial stiffness. Methods Free health examinations were performed on 238 men free of coronary heart diseases (aged 56.5 ± 10.4 years, 57.1% were hypertensive). Carotid–femoral pulse-wave velocity (PWV) was used to assess aortic stiffness. Carotid ultrasound examination included measurements (at sites free of plaques) of intima–media thickness (IMT) at the common carotid arteries (CCA) and assessment of atherosclerotic plaques in the extracranial carotid arteries. Results The percentage of subjects with plaques was lower in subjects with low TIMP-1 values (P for trend = 0.0001). In multivariate analysis adjusted for age, body mass index, smoking habits, total cholesterol, triglycerides, C-reactive protein, heart rate, diabetes and systolic blood pressure, the odds ratio of carotid plaques in subjects with high values of TIMP-1 (tertile 3) compared to those with low values (tertile 1) was 2.89 (95% confidence interval 1.12–7.47, P < 0.01). TIMP-1 was positively associated with CCA-IMT and PWV in univariate analysis. However, the associations disappeared once age and systolic blood pressure were taken into account in the multivariate analysis. Conclusion This study shows that there is a differential association of TIMP-1 with PWV, CCA-IMT and carotid plaques. Our results suggest that TIMP-1 might be involved in plaque formation.