Short-term test results for NTP noncarcinogens: an alternate, more predictive battery.
Short-term test results for NTP noncarcinogens: an alternate, more predictive battery.
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NTP 非致癌物的短期测试结果：替代的、更具预测性的电池。
DOI：
10.1002/em.2860080608
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Rosenkranz,HS
中科院分区：
文献类型：
--
作者：
Ennever,FK;Rosenkranz,HS
用于预测化学品是否为致癌物的一系列短期测试必须既敏感（正确识别致癌物）又特异（正确识别非致癌物）。最近发表的一篇文章[Shelby and Stasiewicz，1984，Environ Mutagen 6：871-876]在国家毒理学计划（NTP）的支持下对70种非致癌物进行了4次短期试验，结果表明短期试验组缺乏特异性。我们使用致癌物预测和电池选择（CPBS）程序分析了这些结果，并计算出NTP电池的特异性确实非常低，即，0.50.利用NTP、EPA的GeneTox计划和WHO国际化学品安全计划的合作研究公布的数据，我们构建了一个具有更少假阳性的替代电池;该电池的特异性为0.80。因此，原始NTP组合缺乏特异性并不意味着没有一组短期试验能够准确预测致癌性。
A battery of short‐term tests used to predict whether or not a chemical is a carcinogen must be both sensitive (correctly identifying carcinogens) and specific (correctly identifying noncarcinogens). A recent publication [Shelby and Stasiewicz, 1984, Environ Mutagen 6:871–876] of results in four short‐term tests for 70 noncarcinogens tested under the aegis of the National Toxicology Program (NTP) indicates that the battery of short‐term tests lacked specificity. We have analyzed these results using the Carcinogen Prediction and Battery Selection (CPBS) procedure and calculated that the specificity of the NTP battery is indeed very low, i.e., 0.50. Using published data from NTP, the GeneTox program of EPA, and the collaborative study of the WHO International Programme on Chemical Safety, we have constructed an alternate battery that has fewer false positives; this battery has a specificity of 0.80. Thus, the lack of specificity of the original NTP battery does not imply that no set of short‐term tests is able to predict carcinogenicity accurately.