EFFECTS OF CHOLINERGIC NERVES ON CEREBRAL BLOOD-FLOW IN CATS
EFFECTS OF CHOLINERGIC NERVES ON CEREBRAL BLOOD-FLOW IN CATS
复制标题
DOI：
10.1161/01.res.48.1.62
复制
发表时间：
1981-01-01
影响因子：
20.1
通讯作者：
HEISTAD, DD
中科院分区：
文献类型：
--
作者：
BUSIJA, DW;HEISTAD, DD
The effects of parasympathetic nerves on cerebral blood flow (CBF) were studied. The greater superficial petrosal nerve, which apparently supplies cholinergic fibers to cerebral vessels and the lacrimal gland, was sectioned on 1 side at the internal auditory meatus in anesthetized cats. CBF was measured with 15 .mu.m microspheres. Section of the petrosal nerve did not alter resting CBF. Electrical stimulation of the distal cut end of the petrosal nerve had no effect on total CBF. In the area of the caudate nucleus, stimulation increased blood flow from 29 .+-. 2 to 36 .+-. 2 (mean .+-. SE) ml/min per 100 g. Lacrimal gland blood flow increased from 42 .+-. 7 to 198 .+-. 32 ml/min per 100 g during petrosal stimulation, indicating potent stimulus. In the same experiments CBF increased 3- to 4-fold during hypercapnia; cerebral vessels were responsive to another dilator stimulus. In other experiments petrosal nerve section did not alter the response of cerebral vessels to hypercapnia (P[partial pressure]CO2 > 50 mm Hg) or hypoxia (PO2 < 34 mm Hg). There is little or no resting vasodilator tone provided to cerebral vessels by the petrosal nerve; petrosal nerve stimulation has a major effect on blood flow to the lacrimal gland, but does not increase CBF; and petrosal nerve section has little effect on the response of cerebral vessels to hypercapnia or hypoxia.
