POTENT, NEW ANALGESICS, TAILOR-MADE FOR DIFFERENT PURPOSES
POTENT, NEW ANALGESICS, TAILOR-MADE FOR DIFFERENT PURPOSES
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DOI：
10.1111/j.1399-6576.1982.tb01765.x
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发表时间：
1982-01-01
影响因子：
2.1
通讯作者：
JANSSEN, PAJ
中科院分区：
文献类型：
--
作者：
JANSSEN, PAJ
There is a variety of conditions linked to intense pain and stress. Some may last for a relatively short period of time, such as certain surgical interventions; others may have a very extended duration. All of these conditions share a common need for potent analgesics that provide sufficient pain relief and alleviation of the stress response. Extensive research in the lield of narcotic analgesics for more than 25 years has led to the development of a series of potent analgesics tailor-made for difrerent purposes.ON ANALGESIA Although opium, the first known analgesic, was used to reiieve pain during operations more than 2000 years ago, administration on a scientific basis was only possible after Serturner in 1806 isolated an active principle of opium which he called “morphicum”, and after Pravaz in 1853 invented the syringe and Wood the hollow needle. Claude Bernard in 1869 was probably the first to investigate the use of morphine for premedication and morphine was used by subcutaneous injection for minor surgery by 1872. In 1900, anaesthesia with morphine (70 mg) and scopolamine was described by Schneiderlein. Patients were oblivious to pain and only 70% required restraint during surgery! This technique, however, caused several deaths and was abandoned after a few years.
